Doğan ATAN, Kürşat Murat ÖZCAN, Nurcan YURTSEVER KUM, Hüseyin DERE

Tıkayıcı uyku apne sendromunun ve sürekli pozitif havayolu basıncı titrasyonunun evre 3 ve REM uykusuna etkisi

Amaç: Bu çalışmada tıkayıcı uyku apnesi sendromu TUAS hastalarında hastalık şiddetinin ve sürekli pozitif havayolu basıncı SPHB titrasyonunun evre 3 ve REM rapid eye movement uykusu üzerine etkisi araştırıldı.Hastalar ve Yöntemler: Çalışmaya polisomnografi PSG ile orta veya ağır TUAS tanısı konulan 114 hasta 87 erkek, 27 kadın, ort. yaş 51.1±10.5 yıl; dağılım 34-66 yıl dahil edildi. Apne hipopne indeksi ve uyku evrelerinin yüzde değerleri ayrı ayrı istatistiksel olarak karşılaştırıldı. Sürekli pozitif havayolu basıncı titrasyonu sırasında hesaplanan uyku evrelerinin yüzde değerleri tespit edildi ve ilk PSG ile karşılaştırıldı.Bulgular: Polisomnografi sonucuna göre 114 hastanın 41’i orta 30 erkek, 11 kadın; ort. yaş 49.8±10.2 yıl , 73’ü ağır 57 erkek, 16 kadın; ort. yaş 51.8±10.8 yıl TUAS idi. Apne hipopne indeksi arttıkça evre 2 uykusu artarken, evre 3 ve REM uykusu azaldı; değişimler istatistiksel olarak anlamlı idi p

Anahtar Kelimeler:

Sürekli pozitif havayolu basıncı, polisomnografi, uyku apne sendromu, uyku evreleri

The effect of obstructive sleep apne syndrome and continuous positive airway pressure titration on stage 3 and REM sleeps

Objectives: This study aims to investigate the effect of disease severity and continuous positive airway pressure CPAP titration on stage 3 and rapid eye movement REM sleeps in obstructive sleep apnea syndrome OSAS patients. Patients and Methods: The study included 114 patients 87 males, 27 females; mean age 51.1±10.5 years; range 34 to 66 years who were diagnosed as moderate or severe OSAS with polysomnography PSG . Percentage values of apnea hypopnea index and sleep stages were individually statistically compared. Percentage values of sleep stages calculated during CPAP titration were determined and compared with first PSG. Results: According to the polysomnography result, of 114 patients, 41 were moderate 30 males, 11 females; mean age 49.8±10.2 years , 73 were severe 57 males, 16 females; mean age 51.8±10.8 years OSAS. As the apnea hypopnea index increased, stage 2 sleep increased, while stage 3 and REM sleeps decreased; changes were statistically significant p<0.001, p=0.002, p=0.002 . When the sleep stages detected during CPAP titration were compared to the first PSG, stage 3 sleep increased by 22% in moderate OSAS patients and by 45% in severe OSAS patients. While REM sleep did not increase in moderate OSAS patients, it increased by 28% in the severe OSAS patients. Conclusion: When an increase by 40% in stage 3 sleep and by 20% in REM sleep were accepted as rebound during CPAP titration, while there was no rebound at stage 3 and REM sleeps in moderate OSAS, rebound was observed at both stage 3 and REM sleeps in severe OSAS.

Keywords:

Continuous positive airway pressure, polysomnography, sleep apnea syndrome, sleep stages,

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