Erken evre bukkal ve oral dil skuamöz hücreli karsinomlarda tümör kalınlığının okült boyun nodları ile ilişkisi
Amaç: Bu çalışmada erken evre bukkal ve oral dilin skuamöz hücreli karsinomlarında SHK okült boyun nodlarının görülme sıklığı ve tümör kalınlığı ile olan ilişkisi araştırıldı.Hastalar ve Yöntemler: Temmuz 2012 - Haziran 2015 tarihleri arasında oral kavitede SHK 44 bukkal ve 33 oral dil nedeniyle daha önce tedavi edilmemiş 77 hastanın tıbbi kayıtları ve patoloji raporları retrospektif olarak incelendi. Klinik olarak boyun negatif, erken evre lezyonlu hastalar T1 ve T2 çalışmaya alındı ve hastaların klinik-patolojik özellikleri, okült boyun nodu sayısı ve tümör kalınlığı olan ilişkisi incelendi.Bulgular: Okült boyun nodları 27 hastada %46 bukkal ve %27 oral dil bulundu. Her iki grupta da, tümör kalınlığı 5 mm ve üzerine ulaştığında okült boyun hastalığı olasılığı artmıştı. Benzer şekilde, ≤4 mm lezyonlarda seviye I ve II’ye kıyasla, okült boyun nodlarının seviye III’e ulaşması halinde, 5 mm her iki grupta da minimum tümör kalınlığı idi.Sonuç: ≥5 mm tümör kalınlığı, erken evre bukkal ve oral dil SHK’de okült boyun nodları ile anlamlı düzeyde ilişkilidir. Bu hastalarda elektif boyun diseksiyonu yapılmalıdır
Correlation of tumor thickness with occult neck nodes in buccal and oral tongue early squamous-cell carcinomas
Objectives: The aim of this study is to investigate the frequency of occult neck nodes and their relationship with tumor thickness in early squamous-cell carcinomas SCCs of buccal and oral tongue. Patients and Methods: We retrospectively reviewed the medical records and pathology reports of 77 previously untreated patients of SCCs of the oral cavity 44 buccal & 33 oral tongue who underwent tumor excision surgery between July 2012 and June 2015. Patients with early lesions T1 and T2 with clinically negative neck were included and their clinicopathological features, number of occult neck nodes and their correlation with tumor thickness were analyzed. Results: Occult neck nodes were found in 27 patients 46% buccal and 27% oral tongue . In both groups, chances of occult neck disease increased, when the thickness of tumor reached 5 mm or above. Similarly 5 mm was the minimum tumor thickness in both groups in which occult nodes were found up to level III of neck in contrast to level I and II in ≤4 mm lesions. Conclusion: Tumor thickness of ≥5 mm is significantly associated with occult neck nodes in both early buccal and oral tongue SCCs. Elective neck dissection should be done in such cases.
___
- 1. Ross GL, Soutar DS, MacDonald DG, Shoaib T,
Camilleri IG, Robertson AG. Improved staging of
cervical metastases in clinically node-negative patients
with head and neck squamous cell carcinoma. Ann
Surg Oncol 2004;11:213-8.
- 2. Huang SH, Hwang D, Lockwood G, Goldstein DP,
O’Sullivan B. Predictive value of tumor thickness
for cervical lymph-node involvement in squamous
cell carcinoma of the oral cavity: a meta-analysis of
reported studies. Cancer 2009;115:1489-97.
- 3. Kligerman J, Lima RA, Soares JR, Prado L, Dias FL,
Freitas EQ, et al. Supraomohyoid neck dissection in
the treatment of T1/T2 squamous cell carcinoma of
oral cavity. Am J Surg 1994;168:391-4.
- 4. O-charoenrat P, Pillai G, Patel S, Fisher C, Archer D,
Eccles S, et al. Tumour thickness predicts cervical
nodal metastases and survival in early oral tongue
cancer. Oral Oncol 2003;39:386-90.
- 5. Mishra RC, Parida G, Mishra TK, Mohanty S. Tumour
thickness and relationship to locoregional failure
in cancer of the buccal mucosa. Eur J Surg Oncol
1999;25:186-9.
- 6. O’Brien CJ, Lauer CS, Fredricks S, Clifford AR,
McNeil EB, Bagia JS, et al. Tumor thickness influences
prognosis of T1 and T2 oral cavity cancer--but what
thickness? Head Neck 2003;25:937-45.
- 7. Hiratsuka H, Miyakawa A, Nakamori K, Kido Y,
Sunakawa H, Kohama G. Multivariate analysis of
occult lymph node metastasis as a prognostic indicator
for patients with squamous cell carcinoma of the oral
cavity. Cancer 1997;80:351-6.
- 8. Tai SK, Li WY, Yang MH, Chu PY, Wang YF, Chang
PM. Perineural invasion as a major determinant for
the aggressiveness associated with increased tumor
thickness in t1-2 oral tongue and buccal squamous cell
carcinoma. Ann Surg Oncol 2013;20:3568-74.
- 9. Urist MM, O’Brien CJ, Soong SJ, Visscher DW,
Maddox WA. Squamous cell carcinoma of the buccal
mucosa: analysis of prognostic factors. Am J Surg
1987;154:411-4.
- 10. Lim SC, Zhang S, Ishii G, Endoh Y, Kodama K,
Miyamoto S, et al. Predictive markers for late cervical
metastasis in stage I and II invasive squamous
cell carcinoma of the oral tongue. Clin Cancer Res
2004;10:166-72.
- 11. Kurokawa H, Yamashita Y, Takeda S, Zhang M,
Fukuyama H, Takahashi T. Risk factors for late
cervical lymph node metastases in patients with
stage I or II carcinoma of the tongue. Head Neck
2002;24:731-6.
- 12. Sheahan P, O’Keane C, Sheahan JN, O’Dwyer TP.
Effect of tumour thickness and other factors on the
risk of regional disease and treatment of the N0 neck
in early oral squamous carcinoma. Clin Otolaryngol
Allied Sci 2003;28:461-71.
- 13. Kane SV, Gupta M, Kakade AC, D’ Cruz A. Depth of
invasion is the most significant histological predictor
of subclinical cervical lymph node metastasis in early
squamous carcinomas of the oral cavity. Eur J Surg
Oncol 2006;32:795-803.
- 14. Po Wing Yuen A, Lam KY, Lam LK, Ho CM, Wong A,
Chow TL, et al. Prognostic factors of clinically stage I
and II oral tongue carcinoma-A comparative study of
stage, thickness, shape, growth pattern, invasive front
malignancy grading, Martinez-Gimeno score, and
pathologic features. Head Neck 2002;24:513-20.
- 15. Kumar T, Patel MD. Pattern of lymphatic metastasis in
relation to the depth of tumor in oral tongue cancers:
a clinico pathological correlation. Indian J Otolaryngol
Head Neck Surg 2013;65:59-63.