Mehmet DÜZLÜ, Ayça ANT, Hakan TUTAR, Recep KARAMERT, Melih ŞAHİN, Erolcan SAYAR, Nesibe CESUR

Nazal tip doğal katil/T hücreli lenfoma: Olgu serisi ve literatür derlemesi

Nazal tip doğal katil/T hücreli lenfoma nazal kavite ve paranazal sinüslerden kaynaklanan, nadir görülen bir ekstranodal non-Hodgkin lenfoma türüdür. Hızlı ilerleyen bir klinik durum olan nazal doğal katil/T hücreli lenfomanın kesin tanısı klinik şüphenin ardından biyopsi materyalinde immünohistokimyasal analiz yapılması sonucu konabilir. Bu yazıda, kliniğimizde takip edilen dört nazal doğal katil/T hücreli lenfoma olgusu bildirildi ve hastalığın tanı ve tedavisi literatür verileri ışığında tartışıldı

Anahtar Kelimeler:

Kemoterapi, nazal kavite, doğal katil/T hücreli lenfoma, radyoterapi

Nasal type natural killer/T cell lymphoma: case series and literature review

Nasal type natural killer/T-cell lymphoma is a rare type of extranodal non-Hodgkin lymphoma which originates from nasal cavity and paranasal sinuses. Exact diagnosis of nasal natural killer/T-cell lymphoma, which is a rapidly progressive clinical condition, may be established by immunohistochemical analysis on biopsy material after clinical suspicion. In this article, we report four cases of nasal natural killer/T-cell lymphoma who were followed-up in our clinic and discuss the diagnosis and treatment of the disease in light of the literature data.

Keywords:

Chemotherapy, nasal cavity, natural killer/T cell lymphoma, radiotherapy,

PDF

___

Jaffe ES, Harris NL, Stein H, Vardiman JW. Pathology and genetics of tumours of haematopoietic and lymphoid tissues. Lyon: IARC Press; 2001.
Ooi GC, Chim CS, Liang R, Tsang KW, Kwong YL. Nasal T-cell/natural killer cell lymphoma: CT and MR imaging features of a new clinicopathologic entity. AJR Am J Roentgenol 2000;174:1141-5.
Jaffe ES, Krenacs L, Kumar S, Kingma DW, Raffeld M. Extranodal peripheral T-cell and NK-cell neoplasms. Am J Clin Pathol 1999;111:46-55.
Aozasa K, Zaki MA. Epidemiology and pathogenesis of nasal NK/T-cell lymphoma: a mini-review. ScientificWorldJournal 2011;11:422-8.
Al-Hakeem DA, Fedele S, Carlos R, Porter S. Extranodal NK/T-cell lymphoma, nasal type. Oral Oncol 2007;43:4-14.
Mestiri S, Zeglaoui I, Sriha B, Belcadhi M, Bouzouita K, Korbi S. Extra-nodal T lymphomas of the nasal cavities and sinuses. Ann Otolaryngol Chir Cervicofac 2008;125:188-92. [Abstract]
Kato N, Yasukawa K, Onozuka T, Kikuta H. Nasal and nasal-type T/NK-cell lymphoma with cutaneous involvement. J Am Acad Dermatol 1999;40:850-6.
Zhong BN, Zhang XH, Li M, Cao HG, Li N, Liu CY, et al. Study of the pathology, immunophenotype, etiology and genetic marker of NK/T-cell lymphoma. Zhonghua Xue Ye Xue Za Zhi 2003;24:505-9. [Abstract]
Wu X, Li P, Zhao J, Yang X, Wang F, Yang YQ, et al. A clinical study of 115 patients with extranodal natural killer/T-cell lymphoma, nasal type. Clin Oncol (R Coll Radiol) 2008;20:619-25.
Jaccard A, Hermine O. Extranodal natural killer/T-cell lymphoma: advances in the management. Curr Opin Oncol 2011;23:429-35.
Cleary KR, Batsakis JG. Sinonasal lymphomas. Ann Otol Rhinol Laryngol 1994;103:911-4.
Kubat G, Mülazimoğlu S, Kaygusuz G, Küçük B, Yorulmaz İ. İnvaziv fungal sinüzit ile karışan sinonazal ekstranodal NK/T hücreli lenfoma: Olgu sunumu. KBB-Forum 2013;13:98-103.
Liang R. Advances in the management and monitoring of extranodal NK/T-cell lymphoma, nasal type. Br J Haematol 2009;147:13-21.
Vose J, Armitage J, Weisenburger D. International peripheral T-cell and natural killer/T-cell lymphoma study: pathology findings and clinical outcomes. J Clin Oncol 2008;26:4124-30.
Schmitz N, Trümper L, Ziepert M, Nickelsen M, HoAD, Metzner B, et al. Treatment and prognosis of mature T-cell and NK-cell lymphoma: an analysis of patients with T-cell lymphoma treated in studies of the German High-Grade Non-Hodgkin Lymphoma Study Group. Blood 2010;116:3418-25.