Sinan ULUYOL, Saffet KILIÇARSLAN, Özlem YAĞIZ

Serum magnezyum düzeyi ve subjektif tinnitus arasındaki ilişki

Amaç: Bu çalışmada, serum magnezyum düzeyi ve iki taraflı subjektif tinnitus arasındaki ilişki araştırıldı.Hastalar ve Yöntemler: İki taraflı şiddetli tinnitus yakınması tinnitus şiddet indeksine göre şiddetli ve dayanılmaz olarak kabul edilen olan toplam 76 hasta 36 erkek, 40 kadın; ort. yaş 48.5±6.5 yıl; dağılım 43-65 yıl çalışma grubu ve 86 sağlıklı katılımcı 42 erkek, 44 kadın; ort. yaş 43.8±7.3 yıl; dağılım 40-61 yıl kontrol grubu olarak çalışmaya dahil edildi. Her iki grubun serum magnezyum düzeyleri ölçüldü ve istatistiksel olarak karşılaştırıldı.Bulgular: Serum magnezyum konsantrasyonu, kontrol grubu ile karşılaştırıldığında çalışma grubunda anlamlı olarak düşük bulundu 2.3±0.4 m/dL’ye karşın 1.8±0.2, p=0.03 .Sonuç: Serum magnezyum düzeyi ile tinnitus arasındaki anlamlı ilişki subjektif tinnitus patofizyolojisinde magnezyumun önemini göstermektedir

Anahtar Kelimeler:

Magnezyum, patofizyoloji, subjektif tinnitus

Relationship between serum magnesium level and subjective tinnitus

ABSTRACT Objectives: This study aims to assess the relationship between serum magnesium level and bilateral subjective tinnitus. Patients and Methods: The study included a total of 76 patients 36 males, 40 females; mean age 48.5±6.5 years; range 43 to 65 years suffering from severe bilateral subjective tinnitus accepted as severe and catastrophic according to tinnitus severity index as the study group and 86 healthy participants 42 males, 44 females; mean age 43.8±7.3 years; range 40 to 61 years as the control group. Serum magnesium levels of both groups were measured and compared statistically. Results: The serum magnesium concentration was significantly lower in the study group compared to the control group 1.8±0.2 vs. 2.3±0.4 mg/dL, p=0.03 . Conclusion: The significant association between serum magnesium level and tinnitus shows the importance of magnesium in the pathophysiology of subjective tinnitus.

Keywords:

Magnesium, pathophysiology, subjective tinnitus,

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Mİller AR. Epidemiology of tinnitus in adults. In: MİllerAR, Langguth B, De Ridder D, Kleinjung T, editors. Textbook of Tinnitus: Diagnosis and Treatment. 1st ed. New York: Springer; 2010. p. 29-38.
Unterrainer J, Greimel KV, Leibetseder M, Koller T. Experiencing tinnitus: which factors are important for perceived severity of the symptom? Int Tinnitus J 2003;9:130-3.
Pan HC, Sheu ML, Su HL, Chen YJ, Chen CJ, Yang DY, et al. Magnesium supplement promotes sciatic nerve regeneration and down-regulates inflammatory response. Magnes Res 2011;24:54-70.
Cevette MJ, Vormann J, Franz K. Magnesium and hearing. J Am Acad Audiol 2003;14:202-12.
Yenigün A, Doğan R, Aksoy F, Akyüz S, Dabak H. Assessment of tinnitus with tinnitus severity index, tinnitus handicap inventory and distortion product otoacoustic emissions in patients with normal hearing and hearing loss. Kulak Burun Bogaz Ihtis Derg 2014;24:11-6.
Cevette MJ, Barrs DM, Patel A, Conroy KP, Sydlowski S, Noble BN, et al. Phase 2 study examining magnesium- dependent tinnitus. Int Tinnitus J 2011;16:168-73.
Xiong M, Wang J, Yang C, Lai H. The cochlea magnesium content is negatively correlated with hearing loss induced by impulse noise. Am J Otolaryngol 2013;34:209-15.
Gordin A, Goldenberg D, Golz A, Netzer A, Joachims HZ. Magnesium: a new therapy for idiopathic sudden sensorineural hearing loss. Otol Neurotol 2002;23:447- 51.
Joachims Z, Netzer A, Ising H, Rebentisch E, Attias J, Weisz G, et al. Oral magnesium supplementation as prophylaxis for noise-induced hearing loss: results of a double blind field study. Schriftenr Ver Wasser Boden Lufthyg 1993;88:503-16.
Attias J, Sapir S, Bresloff I, Reshef-Haran I, Ising H. Reduction in noise-induced temporary threshold shift in humans following oral magnesium intake. Clin Otolaryngol Allied Sci 2004;29:635-41.
König O, Winter E, Fuchs J, Haupt H, Mazurek B, Weber N, et al. Protective effect of magnesium and MK 801 on hypoxia-induced hair cell loss in new-born rat cochlea. Magnes Res 2003;16:98-105.
Altura BM, Altura BT, Gebrewold A, Ising H, Günther T. Noise-induced hypertension and magnesium in rats: relationship to microcirculation and calcium. J Appl Physiol (1985) 1992;72:194-202.
Haupt H, Scheibe F. Preventive magnesium supplement protects the inner ear against noise- induced impairment of blood flow and oxygenation in the guinea pig. Magnes Res 2002;15:17-25.