Nazal polipli hastalarda kırmızı kan hücresi dağılım genişliği

Amaç: Bu çalışmada nazal polipli NP hastaların kırmızı kan hücresi dağılım genişliği KKDG seviyeleri değerlendirildi ve enflamatuvar bir parametre olarak önemi ve hastalık şiddeti ile muhtemel ilişkisi araştırıldı.Hastalar ve Yöntemler: Ocak 2003 - Eylül 2016 tarihleri arasında 139 NP hastası 87 erkek, 52 kadın; ort. yaş 46.6 yıl; dağılım 22-87 yıl ve nazal septal rekonstrüksiyon cerrahisi olmuş 80 kontrol hastası 59 erkek, 21 kadın; ort. yaş 30.3 yıl; dağılım 17-64 yıl bu retrospektif kontrollü çalışmaya dahil edildi. Polip evresi, bilgisayarlı tomografi BT skoru, periferik kanda eozinofil sayısı, total serum immünoglobulin E IgE ve KKDG verileri tıbbi kayıtlardan elde edildi.Bulgular: Elli altı NP’li hastada %40.28 KKDG normal değerlerin üzerindeydi. Ortalama KKDG, NP’li grupta %15.3906±1.41805, kontrol grubunda ise %14.6413±0.83191 idi. İki grup arasındaki fark istatistiksel olarak anlamlı bulundu p

Anahtar Kelimeler:

Enflamasyon, nazal polip, kırmızı kan hücresi dağılım genişliği

Red blood cell distribution width in patients with nasal polyposis

Objectives: This study aims to evaluate the red blood cell distribution width RDW levels of patients with nasal polyposis NP , and investigate its value as an inflammatory parameter and possible correlation with the severity of the disease. Patients and Methods: Between January 2003 and September 2016, a total of 139 NP patients 87 males, 52 females; mean age 46.6 years; range 22 to 87 years and 80 controls 59 males, 21 females; mean age 30.3 years; range 17 to 64 years , who underwent nasal septal reconstruction surgery, were included in this retrospective controlled study. Data including polyp stage, computed tomography CT score, number of eosinophils in peripheral blood, total serum immunoglobulin E IgE and RDW were obtained from medical records. Results: Red blood cell distribution width was above normal values in 56 NP patients 40.28% . Mean RDW was 15.3906±1.41805% in NP group and 14.6413±0.83191% in the control group. The difference was statistically significant between the two groups p<0.001 . There was no statistically significant correlation between RDW and total serum IgE, number of total eosinophils in peripheral blood, polyp stage, and CT scores. Conclusion: Patients with NP showed significantly increased RDW values compared to controls. Although we failed to demonstrate an association of elevated RDW with the disease severity, this preliminary study may give rise to further prospective studies.

Keywords:

Inflammation, nasal polyp, red blood cell distribution width,

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