Gülsün İNAN, Sevda SERT, SEMA BİRCAN, NERMİN KARAHAN, İ. Metin ÇİRİŞ, Şirin BAŞPINAR, Nilgün KAPUCUOĞLU

Tiroid lezyonlarında tiroid ince iğne aspirasyon biyopsisi ve histopatoloji sonuçlarının karşılaştırılması

Amaç: Tiroid ince iğne aspirasyon biyopsi (IIAB) sonuçları ile opere edilen olguların patoloji rapor sonuçları karşılaştırılarak, tiroid lezyonlarının değerlendirilmesinde fakültemizde IIAB.lerinin etkinliğinin saptanması. Hastalar ve Metod: SDÜ Tıp Fakültesinde 2002-2005 yılları arasında IIAB sonrası tiroidektomi yapılan 83 hastanın sitoloji ve histopatoloji sonuçları karşılaştırıldı. IIAB sonuçları benign, malignite kuşkulu, malign ve yetersiz olarak sınıflandırıldı. Bulgular: Seksen üç IIAB materyalinin 45.i (%54.2) benign, 26.sı (%31.3) yetersiz, 8.i (%9.6) malignite kuşkulu, 4.ü (%4.8) maligndir. Sitoloji sonucu benign olarak değerlendirilen olguların 5.i, malignite kuşkulu olarak değerlendirilen olguların 2.si ve malign olarak değerlendirilen olguların 1.i histolojik olarak maligndir. Çalışmamızda duyarlılık %37.5, özgüllük %81.6, tanı değeri %75.4, yanlış pozitiflik değeri %18.3, yanlış negatiflik değeri %62.5, pozitif prediktif değeri %25, negatif prediktif değeri %88.8.dir. Insidental papiller mikrokarsinom tanısı alan olgular dışlandığında duyarlılık %75, özgüllük %81.6, tanı değeri %81.1, yanlış pozitiflik değeri %18.3, yanlış negatiflik değeri %25, pozitif prediktif değeri %25, negatif prediktif değeri %97.5 olarak bulundu. Sonuç: IIAB, tiroid lezyonlarının değerlendirilmesinde papiller mikrokarsinom tanısı dışlandığında değerli bir tanı yöntemidir.

Anahtar Kelimeler:

Biyopsi, ince-iğne, Duyarlılık ve özgüllük, Testlerin kestirim değeri, Tiroid hastalıkları, Tiroid bezi, Tiroidektomi

The comparison of fine needle aspiration biopsy and histopathology results in thyroid lesions

Purpose: To determine the utility of fine needle aspiration biopsy (FNAB) in the evaluation of thyroid lesions at our faculty by comparing the results of FNAB and pathology report results of the patients who underwent surgery. Patients and Method: We compared the cytologic and histopathologic results of 83 patients who underwent thyroidectomies after FNAB at the Suleyman Demirel University School of Medicine between 2002 and 2005. FNAB results were categorized as benign, suspicious for malignancy, malign and insufficient. Results: The diagnosis of FNAB of 83 cases were benign, insufficient, suspicious for malignancy and malign in 45(54.2%), 26(31.3%), 8(9.6%), 4(4.8%) cases respectively. Five of cases which was cytologically diagnosed as benign, 2 of cases which was cytologically diagnosed as suspicious for malignancy and 1 of case which was cytologically diagnosed as malign were found to be malign histologically. Sensitivity, specificity, accuracy, false-positivity, false-negativity, positive predictive value and negative predictive value were 37.5% 81.6%, 75.4%, 18.3%, 62.5%, 25% and 88.8%, respectively. When the incidental papillary microcarcinomas excluded sensitivity, specificity, accuracy, false-positivity, false-negativity, positive predictive value, negative predictive value were changed to 75%, 81.6%, 81.1%, 18.3%, 25%, 25%, 97.5%, respectively. Conclusion: FNAB is a valuable diagnostic method in the evaluation of thyroid lesions when papillary microcarcinomas excluded.

Keywords:

Biopsy, Fine-Needle, Sensitivity and Specificity, Predictive Value of Tests, Thyroid Diseases, Thyroid Gland, Thyroidectomy,

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