Şirin ÇETİN, İsa DEDE

PANKREAS KANSERİNDE PROGROSTİK FAKTÖRLER

GirişBu çalışmada amaç pankreas kanseri tanısı alan olguların klinik özelliklerinin ve risk faktörleri ile ilişkisinin retrospektif olarak değerlendirilmesi ve pankreatik kanserli hastaların yaşam süresini etkileyen prognostik faktörlerin araştırılmasıdır.Materyal ve MetotÇalışmada pankreas tanısı almış 144 hastanın demografik ve klinik özellikleri incelendi. Demografik ve klinik özelliklerin sağkalım ile ilişkisini incelemek içinistatistiksel analizler yapıldı. Sağkalım eğrilerinin çiziminde Kaplan-Meier metodu kullanıldı. Prognostik faktörlerin sağkalım analizleri log-rank testi kullanılarak hesaplandı.BulgularPankreatik kanserli 144 hastanın ortanca sağkalım süresi 11 ay (%95 CI 8.92-13.07) olarak bulundu. Cox regresyon analizi sonucunda yaş, diyabet, kilo kaybı ve alkol kullanımının pankreatik kanserli hastalarda sağkalımla ilişkilerinin anlamlı olduğu saptandı p

PROGNOSTIC FACTORS IN PANCREATIC CANCER

Introduction This study aims to determine the clinical features of cases with pancreatic cancer as well as their association with risk factors and investigate prognostic factors affecting survival retrospectively. Materials and Methods Demographic and clinical features of 144 patients with pancreatic cancer were evaluated. Statistical analysis was performed to identify the relation between such features and survival. Survival rates were obtained using Kaplan–Meier estimator using. Results Median overall survival of 144 patients with pancreatic cancer were estimated to be 11 months (95% CI 8.92–13.07). Cox regression analysis revealed that age, presence of diabetes, weight loss and consuming alcohol were significantly associated with survival in patients with pancreatic cancer. Discussion This study evaluated the impact of prognostic factors that influence survival rate of patients with pancreatic cancer.

PDF

___

1. Warshaw, A. L. & Castillo, C. F.-d. Pancreatic carcinoma. New England Journal of Medicine 1992; 326: 455-465.
2. Ozkan H, Ozturk H. Pankreas kanserinde epidemiyoloji ve risk faktorleri. MN-Klinik Bilimler 2000; 6(1):39-43.
3. Howlader N, Noone A, Kracho M, et al. SEER Cancer Statistics Review 1975-2009 (Vintage 2009 Populations). Bethesta, MD. National Cancer Institute, 2012.
4. Halfdanarson TR, Rabe KG, Rubin J and Petersen GM: Pancreatic neuroendocrine tumors (PNETs): Incidence, prognosis and recent trend toward improved survival. Ann Oncol 19: 1727 1733, 2008
5. Fortner JG, Klimstra DS, Senie RT, et al. Tumor size is the primary prognosticator for pancreatic cancer after regional pancreatectomy. Ann Surg. 1996;223:147–153.
6. Muniraj T, Jamidar PA, Aslanian HR, 2013. Pancreatic cancer: a comprehensive review and update. Dis Mon, 59, 368-402.
7. Cancer Facts and Figures 2013. Atlanta: American Cancer Society; 2013.
8. Yadav D, Lowenfels A. The epidemiology of pancreatitis and pancreatic cancer. Gastroenterology 2013; 144:1252-61.
9. Larsson SC, Wolk A, Red and processed meat consumption and risk of pancreatic cancer: meta-analysis of prospective studies, Br J Cancer. 2012 ;106(3):603- 607)
10. Chari S, Leibson C, Rabe K, et al. Pancreatic cancancer-associated diabetes mellitus: Prevalence and temporal association with diagnosis of cancer. Gastroenterology 2008; 134:95-101.
11. Lowenfels AB, Maisonneuve P. Epidemiology and risk factors for pancreatic cancer. Best Pract Res Clin Gastroenterol 2006; 20: 197-209.
12. Ryan DP, Grossbard ML. Pancreatic cancer: local success and distant failure. Oncologist 1998; 3: 178-188.
13. Gao Y, Wang WJ, Zhi Q, Shen M, Jiang M, Bian X, Gong FR, Zhou C, Lian L, Wu MY, Feng J, Tao M, Li W. Neutrophil/lymphocyte ratio is a more sensitive systemic inflammatory response biomarker than platelet/lymphocyte ratio in the prognosis evaluation of unresectable pancreatic cancer. Oncotarget. 2017 Sep 27;8(51):88835-88844
14. Peixoto RD, Speers C, McGahan CE, Renouf DJ, Schaeffer DF, Kennecke HF. Prognostic factors and sites of metastasis in unresectable locally advanced pancreatic cancer. Cancer Med. 2015 Aug;4(8):1171-7.
15. Go VLW, Gukovskaya A, Pandol SJ, Alcohol and pancreatic cancer. 2005;35(3):205-211
16. Gullo L, Pezzilli R, Morselli-Labate AM. Diabetes and the risk of pancreatic cancer. N Engl J Med, 1994; 331: 81-84
17. Hassan MM, Bondy ML, Wolff RA, et al. Risk factors for pancreatic cancer. American Journal of Gastroenterology. 2007;102(12):2696-2707
18. AbeloffMD, Armitage JO, Niederhuber JE, Carcinoma of the Pancreas. Clinical Oncology. 4 thed. Philadelphia 2008.p. 1596