Mine GEÇGELEN CESUR, Gözde ÖĞRENİM, Kanat GÜLLE, Fevziye Burcu ŞİRİN, Meryem AKPOLAT, Gökhan CESUR

DOES SHILAJIT HAVE AN EFFECT ON NEW BONE REMODELLING IN THE RAPID MAXILLARY EXPANSION TREATMENT? A BIOCHEMICAL, HISTOPATHOLOGICAL AND IMMUNOHISTOCHEMICAL STUDY

ObjectiveThe goal of this study is to show the effects of shilajit on new bone remodelling after rapid maxillary expansion (RME) in rats utilizing histopathological, biochemical and immunohistochemical techniques.Material and MethodThe rats (12-week-old) were divided into the 3 groups (n=8): no maxillary expansion (NE), only maxillary expansion (OE), maxillary expansion + shilajit (Shilajit).Rats received to shilajit throughout the 5 day expansion and 12 day maintenance time. All rats were sacrificed at the same time. After sacrificing the animals, requiredtissues were taken and histopathological, biochemical and immunohistochemical analysis were performed.ResultsGlutathione peroxidase, superoxide dismutase and catalase levels within the shilajit (shilajit + expansion) group were measurably higher than the OE group (p

SHİLAJİT’İN HIZLI MAKSİLLER GENİŞLETME TEDAVİSİNDE YENİ KEMİK ŞEKİLLENMESİ ÜZERİNE ETKİSİ VAR MI? BİYOKİMYASAL, HİSTOPATOLOJİK VE İMMÜNOHİSTOKİMYASAL BİR ÇALIŞMA

Amaç Bu çalışmanın amacı sıçanlarda hızlı maksiller genişletme (RME) sonrası shilajit’in yeni kemik şekillenmesine etkilerini histopatolojik, biyokimyasal ve immünohistokimyasal teknikler kullanarak göstermektir. Gereç ve Yöntem Wistar Albino türü sıçanlar (12 haftalık) 3 farklı gruba ayrılmıştır (n = 8): üst çenede genişletme yapılmamış (NE), üst çenede sadece genişletme yapılmış (OE), üst çenede genişletmeye ilave olarak shilajit uygulanmış (Shilajit). Sıçanlara 5 günlük genişletme ve 12 günlük retansiyon periyodu süresince shilajit uygulandı. Hayvanlar sakrifiye edildikten sonra gerekli numuneler alınıp histopatolojik, biyokimyasal ve immünohistokimyasal analizler yapıldı. Bulgular Shilajit grubundaki glutatyon peroksidaz, süperoksit dismutaz ve katalaz düzeyleri OE grubundan daha yüksek bulundu (p

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