Ümran AYDEMİR SEZER

Nanocellulose Containing Polymethyl Methacrylate Bone Cements: Effect of Production Process and Silanization on Mechanical Characteristics

Kemik çimentosu, kalça implantlarını sabitlemek için klinik uygulamalarda gerekli ortopedik malzemelerden biridir. Bununla birlikte, kemik çimentosu kullanımı, implantasyon bölgesi ile mekanik uyumsuzluk gibi bazı sınırlamalara tabidir. Bu sınırlamaların üstesinden gelmek için bazı dolgu maddelerinin ve kemik çimentosu formülasyonlarının kullanılmasına rağmen, daha iyi çözümlere hala ihtiyaç vardır. Nanoselülozun (NC), doğal, kristal ve güçlü yapısı sayesinde kemik çimentoları ile formülasyon oluşturmada başarılı sonuçlar vermesi mümkündür. Bu çalışmada, değişik yöntemlerle üretilen NC içeren kemik çimentolarının mekanik performansını ve kemik çimentosundaki değişken oranlarını incelenmiştir. Ayrıca, silanizasyon yöntemiyle karşılaştırmalı bir çalışma ile kompozit teknolojide fazlar arası uyumluluğun arttırılması için kullanılan ve aynı oranların silanize edilmiş ve silanize edilmemiş parçacıklarla NC formülasyonlarında kullanılması araştırılmıştır. Sonuçlar, NC silanizasyonunun, silanize edilmemiş formülasyona kıyasla mekanik mukavemette bir fark yaratmadığını ortaya koymuş, ancak farklı kurutma yöntemleri ile üretilen NC ile önemli fark tespit edilmiştir.

Anahtar Kelimeler:

nanoselüloz, kenik çimentasu, silanizasyon, sprey-kurutma, dondur-kurutma

Nanocellulose Containing Polymethyl Methacrylate Bone Cements: Effect of Production Process and Silanization on Mechanical Characteristics

Bone cement is one of the essential orthopedic materials in clinical applications for fixing hip implants. However, the use of bone cement is subject to some limitations like mechanical mismatch with the implantation site. Despite the use of some fillers and bone cement formulations to tackle these limitations, there is still a need for better solutions. It is possible for nanocellulose (NC) to yield successful results in creating a formulation with bone cements thanks to its natural, crystal and strong structure. In this study, the mechanical performance of bone cements containing NC that is produced with varying methods, and varying ratios in bone cement was examined. Moreover, a comparative study by the silanization method; which is used for enhancing the inter-phase compatibility in composite technology; and employing the same ratios in NC formulations with silanized and non-silanized particles was conducted. The results revealed that the silanization of NC does not create a difference in mechanical strength compared to the non-silanized formulation, however, a significant difference was detected with NC produced by different drying methods.

Keywords:

nanocellulose, bone cement, silanization, sprya-drying, freeze-drying,

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