Erdal BİLEN, Murat YÜKSEL, Mekin SEZİK, Seyit Ali KÖSE, ESRA NUR TOLA

Gebeliğin 11-14 haftasında karyotipleme lı koryon villüs biyopsisi: 42 Olgunun değerlendirilmesi

Amaç: Koryon villüs biyopsi (CVS) girişimlerindeki endikasyonların dağılımı, yaşa göre oranları, girişim işlemleri ve karyotip sonuçlarının incelenmesidir.Materyal-Metot: Ocak 2008-Şubat 2013 tarihleri arasında Süleyman Demirel Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum kliniğinde yüksek riskli gebeliklerde karyotip amaçlı yapılan CVS sonuçları geriye dönük olarak değerlendirilmiştir.Bulgular: Toplam kırk iki olgu incelendi. Hastaların % 19'u 18-25, % 36'sı 26-33, % 45'i 34-41 yaş aralığındaydı. CVS işlemleri, ortalama 12.1 ± 1.3 gebelik haftasında (dağılım, 11-15 hafta) uygulandı. Olguların % 35.7'sinde (n=15) kromozom anomalisi saptandı. CVS sırasında ve sonrasındaki 72 saatte gebelik kaybı görülmedi. Tartışma: Kromozom anomalilerinin erken gebelik haftalarında saptanmasında CVS değerli ve nispeten güvenli bir yöntemdir.

Chorion villus sampling for karyotyping at 11-14 weeks of gestation: Evaluation of 42 cases

Objective: To evaluate indications, maternal and gestational age distribution, invasive methods, and karyotype results of chorion villus sampling (CVS) proceduresMaterial-Method: CVS results performed for karyotyping in high-risk pregnancies at Suleyman Demirel University obstetrics and gynecology clinics between January 2008-February 2013 were retrospectively investigated.Results: Forty-two cases were included. Maternal age was between 18-25 years in 19%, 26-33 years in 36%, and 34-41 years in 45%. Mean gestational week at the procedure was 11.2 ± 1.2 (range, 11-15 weeks). A chromosomal abnormality was detected in 35.7% (n=15) of the cases. There were no fetal losses during or after 72 hours of the CVS procedures.Discussion: CVS is a valuable and relatively safe method for the detection of chromosomal abnormalities at early gestation.

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