Çölyak Hastalığının Sıklık Artışında Helicobacter Pylori’nin Etkisi

Amaç: Çölyak hastalığının rastlanma sıklığına Helicobacter pylori’nin etkisi araştırıldı. Gereç ve Yöntemler: Histolojik ve serolojik olarak teşhis edilen 38 çölyak hastası (27 kadın, 11 erkek) çalışmaya dahil edildi. Ayrıca çölyak ile uyumlu bulgu saptanmamış 50 hasta da araştırmaya ilave edildi. İki grubun Helicobacter pylori prevalansları saptanarak aralarında farklılık olup olmadığı araştırıldı. Bulgular: Çölyak hastalığı olgularının 20’sinde (%52,6), çölyak hastalığı olmayan grupta 36 (%72,0) hastada Helicobacter pylori pozitif bulundu. Çölyak hastaları grubu ile çölyak olmayan hastalar grubu arasında, Helicobacter pylori enfeksiyonu görülmesi bakımından, istatistiksel olarak anlamlı farklılık saptanmadı (p=0,100). Sonuç: Helicobacter pylori ile çölyak hastalığı arasındaki ilişki tartışmalıdır. Helicobacter pylori ile çölyak hastalığı arasındaki bağlantıyı anlamak için virülans araştırmaları da yapılmalıdır.

Effect of Helicobacter Pylori in Increasing Prevalence of Celiac Disease

Objective: Investigating the effect of helicobacter pylori on the prevalence of celiac disease. Material and Methodology: 38 celiac patients diagnosed in histologic and serologic terms (27 women and 11 men) were included in the survey. 50 more patients with no indication of celiac were also included in order to see if there is any difference by determining their helicobacter pylori prevalence. Findings: Helicobacter pylori turned out as positive in 20 cases with celiac disease (52.6%) and in 36 cases without the disease (72%). No statistically significant difference was found between the two groups in terms of helicobacter pylori infection (p=0.100). Conclusion: The relationship between helicobacter pylori and celiac disease is debatable. There is need to conduct virulence surveys as well to go deeper in understanding this relationship.

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