Diş hekimliğinde kullanılan kök hücre tipleri: Literatür derlemesi

Kök hücreler, hem rejeneratif tıp uygulamalarında hem de doku rejenerasyonunda kullanılan ve dental dokular da dahil olmak üzere çok çeşitli doku ve organlardan izole edilen prekürsör hücrelerdir. Hem doku mühendisliğinde hem de klinik uygulamalarda kullanılan kök hücreler, odontoblastlardan nöral hücrelere kadar birçok hücreye dönüşebilme yeteneğine sahiptir. Diş hekimliği alanında yetişkin mezenkimal kök hücreler çeşitli oral ve maksillofasiyal dokularda tanımlanmıştır; bu da oral dokuların kök hücrelerden zengin olduğunu ve mukozal hücrelerin indükte pluripotent kök hücreler gibi genetik olarak yeniden programlanmış hücreler için ideal kaynak olabileceğini göstermiştir. Ayrıca oral dokuların kök hücreler için yalnızca bir kaynak değil, aynı zamanda terapötik bir hedef olması da beklenmektedir. Bu derlemede, diş hekimliği alanındaki klinik kullanılabilirlik ve uygulamalar açısından çeşitli intra ve ekstraoral doku kökenli kök hücre tiplerine ve rejeneratif diş hekimliği için uygun kök hücrelere genel bir bakış açısı sunulmaktadır.

Types of stem cells used in dentistry: A review of literature

Stem cells are precursor cells that are used both in regenerative medicine applications and tissue regeneration and isolated from a wide variety of tissues and organs, including dental tissues. The stem cells used in both tissue engineering and clinical practice have the ability to transform into many different cells, such as odontoblasts and neural cells. In the field of dentistry, adult mesenchymal stem cells have been described in various oral and maxillofacial tissues; suggesting that oral tissues are rich stem cell souces and mucosal cells may be the ideal source for genetically reprogrammed cells such as inducible pluripotent stem cells. It is also expected that the oral tissues will not only be a source for stem cells, but they will also be a therapeutic target. In this review, we present a general overview of stem cells suitable for intra and extraoral tissue derived stem cell types and suitable stem cells for regenerative dentistry in terms of clinical usability and applications in dentistry.

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Selcuk Dental Journal-Cover
  • ISSN: 2148-7529
  • Yayın Aralığı: Yılda 3 Sayı
  • Başlangıç: 2014
  • Yayıncı: Selcuk Universitesi Dişhekimliği Fakültesi