Kübra Gülnur Topsakal, Yasemin Nur Korkmaz

KÖK HÜCRELER VE DİŞ HEKİMLİĞİ: LİTERATÜR DERLEMESİ

Kök hücreler, hem rejeneratif tıp uygulamalarında hem de doku rejenerasyonunda kullanılan ve dental dokular da dahil olmak üzere çok çeşitli doku ve organlardan izole edilen prekürsör hücrelerdir. Hem doku mühendisliğinde hem de klinik uygulamalarda kullanılan kök hücreler, odontoblastlardan nöral hücrelere kadar birçok hücreye dönüşebilme yeteneğine sahiptir. Diş hekimliği alanında yetişkin mezenkimal kök hücreler çeşitli oral ve maksillofasiyal dokularda tanımlanmıştır; bu da oral dokuların kök hücrelerden zengin olduğunu ve mukozal hücrelerin indükte pluripotent kök hücreler gibi genetik olarak yeniden programlanmış hücreler için ideal kaynak olabileceğini göstermiştir. Ayrıca oral dokuların kök hücreler için yalnızca bir kaynak değil, aynı zamanda terapötik bir hedef olması da beklenmektedir. Bu derlemede, diş hekimliği alanındaki klinik kullanılabilirlik ve uygulamalar açısından çeşitli intra ve ekstraoral doku kökenli kök hücre tiplerine ve rejeneratif diş hekimliği için uygun kök hücrelere genel bir bakış açısı sunulmaktadır.

Anahtar Kelimeler:

Kök hücre, doku mühendisliği

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