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TİROİD TÜMÖRLERİNDE İMMÜNOHİSTOKİMYASAL OLARAK NEOVASKÜLER PSMA VE CD34 EKSPRESYONLARININ DEĞERLENDİRİLMESİ

Amaç Bu çalışmanın amacı tiroid tümörlerinde Prostat Spesifik Membran Antijen (PSMA) ekspresyonunun ayrıcı tanıdaki yeri ve prognoz üzerine etkisinin araştırılmasıdır. Gereç ve Yöntem Farklı histolojik tipteki 95 tiroid kanseri tanısı alan hastaların parafin bloklarına immünohistokimyasal PSMA ve CD34 uygulandı. Tümöral ve ekstratümoral stromadaki vasküler ekspresyon yüzdesi ve tümör epitelindeki yoğunluk skoru değerlendirildi ve PSMA ekspresyon düzeyine göre gruplara ayrıldı. Nihai PSMA ifadesi, yoğunluk ve yüzde puanları çarpılarak belirlendi. Bulgular Tiroid tümörlerinde yeni damar oluşumu olan alanlarda PSMA ile ekspresyon artışı izlendi. Non-neoplastik tiroid dokusunda PSMA ile vasküler boyanma saptanmadı. Papiller Benzeri Nükleer Özellikler Gösteren Noninvaziv Foliküler Neoplazi (NİFTP) vakalarında agresif tümörlere göre karşılaştırıldığında ekspresyon artışı görülmedi Sonuç PSMA ekspresyon artışının kötü prognozla ilişkili olduğu saptandı ve NİFTP vakalarının diğer tümörler ile ayrımında kullanılabileceği yönünde bulgular saptandı

Anahtar Kelimeler:

Neovaskülarizasyon, PSMA ekspresyonu, Tiroid Karsinomu

EVALUATION OF IMMUNOHISTOCHEMICAL NEOVASCULAR PSMA AND CD34 EXPRESSIONS IN THYROID TUMORS

Objective The aim of this study was to investigate the place of Prostate Specific Membrane Antigen (PSMA) expression in differential diagnosis and its effect on prognosis in thyroid tumors. Material and Method Immunohistochemical PSMA and CD34 were applied to paraffin blocks of 95 patients diagnosed with different histological types of thyroid cancer. The percentage of vascular expression in the tumoral and extratumoral stroma and the density score in the tumor epithelium were evaluated and grouped according to PSMA expression level. Final PSMA expression was determined by multiplying intensity and percentage points. An increase in expression was observed with PSMA in areas with neovascularization in thyroid tumors. No vascular staining was detected with PSMA in nonneoplastic thyroid tissue. No increase in expression was seen in Non-invasive folicular thyroid neoplasm with papillary like nuclear features (NIFTP) cases compared to aggressive tumors Conclusion It was determined that increased PSMA expression was associated with poor prognosis, and it was found that it can be used to differentiate NIFTP cases from other tumors.

Keywords:

Neovascular, PSMA Expression, Thyroid Cancer,

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