Ramazan Oğuz YÜCEER, Mehmet KIRAN, İbrahim Metin ÇİRİŞ, Yusuf Çağdaş KUMBUL, Kayhan BAŞAK

PAROTİS BEZİNİN HİGH GRADE ONKOSİTİK MUKOEPİDERMOİD KARSİNOMU, MAML2 TRANSLOKASYONU, NADİR BİR OLGU

Mukoepidermoid karsinom (MEK) tükürük bezinin en sık görülen malign tümörüdür ve en sık parotiste görülür. Onkositik mukoepidermoid karsinom (OMEK) nadir subtiptir. Burada 28 yaşında endometrium kanseri nedeniyle takip edilen kadın hastanın, sağ parotiste izlenen kitlesinin primer tümör mü metastatik tümör mü olduğunu histolojik, immünhistokimyasal ve moleküler sonuçlarıyla sunmayı amaçladık.

Anahtar Kelimeler:

Mukoepidermoid karsinom, parotis, onkositik, MAML2

HIGH-GRADE ONCOCYTIC MUCOEPIDERMOID CARCINOMA OF PAROTID GLAND, MAML2 TRANSLOCATION, A RARE CASE

Mucoepidermoid carcinoma (MEC) is the most common malignant tumor of the salivary gland and is most commonly seen in the parotid. Oncocytic mucoepidermoid carcinoma (OMEC) is a rare subtype. Here, we aimed to present the histological, immunohistochemical, and molecular results of a 28-year-old female patient followed for endometrial cancer, whether the mass in the right parotid is a primary or metastatic tumor.

Keywords:

Mucoepidermoid carcinoma, oncocytic, parotid, MAML2,

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1. Rapidis AD, Givalos N, Gakiopoulou H, Stavrianos SD, Faratzis G, Lagogiannis GA, et al. Mucoepidermoid carcinoma of the salivary glands. Review of the literature and clinicopathological analysis of 18 patients. Oral oncology. 2007;43(2):130-6.
2. El-Naggar AK GJ, Slootweg PJ, Chan JKC, Takata T WHO Classification of Tumours of the Head and Neck. WHO/IARC Classification of Tumours of the Head and Neck. , 4th edn Lyon: IARC Presslow. 2017.
3. Qureshi, S., Janjua, O.S., & Janjua, S.M. (2012). Mucoepidermoid carcinoma:A clinicopathological review of 75 cases. International Journal of Oral and Maxillofacial Pathology, 3, 5-9.
4. Ellis GL AP. Atlas of Tumor Pathology. Tumors of the Salivary Glands. Amer Registry of Pathology; 1st edition (January 1, 1992)
5. Cipriani NA, Lusardi JJ, McElherne J, Pearson AT, Olivas AD, Fitzpatrick C, Lingen MW, Blair EA. Mucoepidermoid Carcinoma: A Comparison of Histologic Grading Systems and Relationship to MAML2 Rearrangement and Prognosis. Am J Surg Pathol. 2019 Jul;43(7):885-897. doi: 10.1097/ PAS.0000000000001252. PMID: 31021855; PMCID:PMC6629427.
6. Behboudi A, Enlund F, Winnes M, Andrén Y, Nordkvist A, Leivo I, et al. Molecular classification of mucoepidermoid carcinomas- prognostic significance of the MECT1-MAML2 fusion oncogene. Genes, chromosomes & cancer. 2006;45(5):470-81.
7. León X, Szafranska J, Méndez JE. A case of necrotizing sialometaplasia. Acta otorrinolaringologica espanola. 2020;71(5):328-9.
8. Tandon A, Jaiswal R, Siddiqui S, Bordoloi B. Keratinizing pleomorphic adenoma: An unusual case report. Journal of oral and maxillofacial pathology : JOMFP. 2018;22(Suppl 1):S69-s72.
9. Yorita K, Nakagawa H, Miyazaki K, Fukuda J, Ito S, Kosai M. Infarcted Warthin tumor with mucoepidermoid carcinoma-like metaplasia: a case report and review of the literature. Journal of medical case reports. 2019;13(1):12.
10. Damjanov I, Skenderi F, Vranic S. Mammary Analogue Secretory Carcinoma (MASC) of the salivary gland: A new tumor entity. Bosnian journal of basic medical sciences. 2016;16(3):237-8.
11. Panchbhai AS. Primary squamous cell carcinoma of salivary gland: Report of a rare case. Journal of cancer research and therapeutics. 2015;11(3):664.
12. Birkeland AC, Foltin SK, Michmerhuizen NL, Hoesli RC, Rosko AJ, Byrd S, et al. Correlation of Crtc1/3-Maml2 fusion status, grade and survival in mucoepidermoid carcinoma. Oral oncology. 2017;68:5-8.