Ali Serdar OĞUZOĞLU, Nilgün ŞENOL, Hasan YASAN, Ramazan Oğuz YÜCEER, İbrahim Metin ÇİRİŞ

PROSTAT-SPESİFİK MEMBRAN ANTİGEN MENENGİOM TEDAVİSİNDE YER ALABİLİR Mİ?

Amaç Tümör oluşumunda ve ayırıcı tanısında tümör anjiogenezi önemli bir unsur ve değerli bir göstergedir. Menengiomlar vasküleritesi yüksek tümörler olması nedeni ile bu çalışmada, farklı tedavi protokollerinin geliştirilebilmesi açısından menengiomlarda immunohistokimyasal yöntemlerle prostat-spesifik membran antijen (PSMA) salınımının değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem Kliniğimizde opere edilerek Derece I (n=32), Derece II (n=6) ve Derece III (n=10) menengiom tanısı almış 48 hastadan alınmış olan doku örneklerinde PSMA antikorları immunohistokimyasal metod ile incelendi. Tümör dokusundaki PSMA boyanma yoğunluğu ve yüzdesi incelendi. Tümör epitelinde tümör ve tümör-dışı dokuda PSMA salınımına göre vasküler salınım ve yoğunluk skoru analiz edildi. Bulgular Farklı derecelerdeki menengiom preparatlarında yapılan immunohistokimyasal analizler tümör epitelinde ve stromasında PSMA salınım ve yoğunluk skorları arasında istatistiksel olarak anlamlı farklılık olmadığını gösterdi (p>0.05). Sonuç Agresif seyreden, rezeke edilemeyen menegiomlarda anjiogeneziste rol alan bazı moleküler biomarkerlar önem kazanmaktadır. Her ne kadar PSMA açısından anlamlı sonuçlar elde edilmemiş olsa da moleküler ve genetik teknikler geliştikçe tümör biyolojisinin ortaya konup potansiyel hedeflerin belirlenmesi yeni tedavi yolları açacaktır.

Anahtar Kelimeler:

menengiom, antijen, prostat-spesifik membran, anjiogenez

CAN PROSTATE-SPECIFIC MEMBRANE ANTIGENE TAKE PART IN MENENGIOMA TREATMENT?

Objective In tumor development, tumor angiogenesis is an essential component, and a valuable marker in the differantial diagnosis of brain tumors. As menengiomas are highly vascular tumors in this study, we aimed to evaluate the expression of prostate-spesific membrane antigen (PSMA) in menengiomas by immunohistochemistry method to determine different target therapies. Material and Method Pathologic specimens with the diagnosis Grade I (n=32), Grade II (n=6) ve Grade III (n=10) of 48 patients operated for menengioma in our clinic, were evaluated for PSMA-antibody via immunohistochemical method. PSMA staining intensities in tumor tissue and tumor epithelium were analyzed. Vascular expression in tumoral and extratumoral stroma, and intensity score, according to PSMA expression, in tumoral epithelium were analyzed. Results Immunohistochemical analyses of different grade menengioma specimens showed no statistically significant differences between PSMA expression and PSMA staining intensities in tumor tissue and tumor epithelium (p>0.05). Conclusion Some molecular biomarkers, that take part in angiogenesis of agressive and unresectable menengiomas come into prominence. Although no significant results were achieved in terms of PSMA, as the molecular and genetic techniques progress, tumor biology manifestation and determination of potential targets will lead to new treatment procedures.

Keywords:

menengioma, antigen, prostate-spesific membrane, angiogenesis,

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