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• 1. Aboderin IA, Beard JR. Older people’s health in sub-Saharan Africa. Lancet. 2015; Feb 14;385(9968):e9-11
• 2. (http://www.tuik.gov.tr;08.07.2010) Saglik Bakanligi 2010 yili istatistikleri- Saglik Bakanligi Yayinlari, 2010;Ankara
• 3. Morioka T, Miyazaki H, Tsuruta K. Problems in neurosurgical operations on elderly patients-from the viewpoint of Anesthesiology. Neurol Med Chir (Tokyo) 1980;20:713-720
• 4. Delafuente JC. The silver tsunami is coming: Will pharmacy be swept away with the tide? Am J Pharm Educ 2009;73:1
• 5. Janelsins MC, Kohli S, Mohile SG, Usuki K, Ahles TA, Morrow GR. An update on cancer and chemotherapy related cognitive dysfunction:current status. Semin Oncol 2011;38(3):431-438
• 6. Loh D, Hogg F, Edwards P, MacColl J,Brogna C,Bhangoo R. Two year experience of multi-disciplinary team (MDT) outcomes for brain metastases in a tertiary neuro-oncology centre. British J of Neurosurgery, 2017;https://doi.org/10.1080/02688697.2017.1368449
• 7. Weller M, Platten M, Roth P, Wick W. Geriatric neuro-oncology: from mythology to biology. Neurology 2011;24:599-604
• 8. Dolecek TA, Propp JM, Stroup NE, et al. CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2005-2009. Neuro-Oncol. 2012;14(5):v1-v49
• 9. Pruitt AA. Medical management of patients with brain tumors. Curr Treat Options Neurol 2011;13:413-426
• 10. Chargari C, Feuvret L, Bauduceau O, et al. Treatment of elderly patients with glioblastoma: From clinical evidence to molecular highlights. Cancer Treat Rev. 2012;38(8):988-995
• 11. Batchelor TT, Betensky RA, Esposito JM, et al. Age-dependent prognostic effects of genetic alterations in glioblastoma. Clin Cancer Res. 2004;10(1 Pt 1):228-233
• 12. McDonald KL, McDonnell J, Muntoni A, et al. Presence of alternative lengthening of telomeres mechanism in patients with glioblastoma identifies a less aggressive tumor type with longer survival. J Neuropathol Exp Neurol. 2010;69(7):729-736
• 13. Ohgaki H, Kleihues P. The definition of primary and secondary glioblastoma. Clin Cancer Res. 2013;19(4):764-772
• 14. Bauchet L, Zouaoui S, Darlix A, Champfleur NM, Ferreira E, Fabbro M, Kerr C, Taillandier L. Assessment and treatment relevance in elderly glioblastoma patients. Neuro-Oncology 2014;16(11):1459-1468
• 15. Hegi ME, Diserens A-C, Gorlia T, et al. MGMT Gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med 2005;352(10):997-1003
• 16. Perez-Larraya JG, Delattre JY. Management of elderly patients with gliomas. The Oncologist 2014;19:1258-1267
• 17. Drappatz J, Schiff D, Kesari S, et al. Medical management of brain tumor patients. Neurol Clin 2007;25:1035-1071
• 18. Arif H, Buchsbaum R, Pierro J et al. Comparative effectiveness of 10 antiepileptic drugs in older adults witj epilepsy. Arch Neurol 2010;67:408-415
• 19. Waterhouse E, Towne A. Seizures in the elderly: Nuances in presentation and treatment. Cleve Clin J Med 2005;72(suppl 3):S26-S37
• 20. Johans SJ, Garst JR, Burkett DJ, Grahnke K, Martin B, Ibrahim TFm Anderson DE, Prabhu VC. Identification of preoperative and intraoperative risk factors for complications in the elderly undergoing elective craniotomy. World Neurosurgery 2017;107:216-225
• 21. Laigle-Donadey F, Sanson M. Pattern of care of high-grade gliomas. Rev Prat 2006;56:1779-1786
• 22. Chaichana KL, Garzon_Muvdi T, Parker S et al. Supratentorial glioblastoma multiforme: the role of surgical resection versus biopsy among older patients. Ann Surg Oncol 2011;18:239-245
• 23. D’Amico RS, Cloney MB, Sonabend AM, Zacharia B, Nazarian MN, Iwamoto FM, Sisti MB, Bruce JN, McKhann GM. The safety of surgery in elderly patients with primary and recurrent glioblastoma. World Neurosurgery 2015;84(4):913-919
• 24. Crossen JR, Garwood D, Glatstein E, Neuwelt EA. Neurobehavioral sequelae of cranial irradiation in adults: a review of radiation-induced encephalopathy. J Clin Oncol 1994;12:627-42
• 25. Stupp R, Mason WP, van den Bert MJ, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 2005;352(10):987-996
• 26. Roa W, Brasher PM, Bauman G, et al. Abbreviated course of radiation therapy in older patients with glioblastoma multiforme: a prospective randomized clinical trial. J Clin Oncol. 2004;22(9):1583-1588
• 27. Perez-Larraya, Ducray F, Chinot O, Thomas IC, Taillandier L, Guillamo JS et al. Temozolomide in elderly patients with newly diagnosed glioblastoma and poor performance status: an ANOCEF phase II trial. Journal of Clınıcal Oncology 2011;29(22):3050-3055
• 28. Holdhoff M, Chamberlain MC. Controversies in the treatment of elderly patients with newly diagnosed glioblastoma. J Natl Compr Canc Netw. 2013;11(9):1165-1173
• 29. Kono M, Arakawa Y, Mineharu Y, Ohka F, Kinoshita M, Nakae S, Miyashita K, Luchi T, Hirose Y, Natsume A. et al. P09.50 Phase I tial of temozolomide plus bevacizumab for newly diagnosed high-grade gliomas in the elderly: Interim report. Neuro-Oncology 2017;19(3):81
• 30. Malmstrom A, Gronberg BH, Marosi C, et al. Temozolomide versus standart 6-week radiotherapy versus hypofractioned radiotherapy in patients older than 60 years with glioblastoma: the Nordic randomized, phase 3 trial. Lancet Oncol. 2012;13(9):916-926
• 31. Wick W, Platten M, Meisner C, et al. Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trial. Lancet Oncol. 2012;13(7):707-715
• 32. Minniti G, Lanzetta G, Scaringi C, Caporello P, Salvati M, Arcella A, et al. Phase II study of short-course radiotherapy plus concomitant and adjuvant temozolomide in elderly patients with glioblastoma. Int J Radiat Oncol Biol Phys. 2012;83(1):93-9
• 33. Perez-Larraya JG, Delattre JY. Treating glioblastoma in the elderly. CNS Oncol 2012;1:193-201
• 34. Gehring K, Patwardhan SY, Collins R et al. A randomized trial on the efficacy of mthylphenidate and modafinil for improving cognitive functioning and symptoms in patients with primary brain tumor. J Neurooncol 2012;107:165-174
• 35. Cloney M, D’Amico R, Lebovic J, Nazarian M, Zacharia BE, Sisti MB, Bruce JN, McKhann GM, Iwamoto FM, Sonabend AM. Frailty in geriatric glioblastoma patients: a predictor of operative morbidity and outcome. World Neurosurgery 2016;89:362-367
• 36. Decoster L, Van Puyvelde K, Mohile S, Wedding U, Basso U, Colloca G et al. Screening tools for multidimensional health problems warranting a geriatric assessment in older cancer patients: an update on SIOG recommendations. Ann Oncol 2015;26(2):288-300
• 37. Pallis AG, Fortpied C, Wedding U, et al. EORTC elderly task force position paper: Approach to the older cancer patient. Eur J Cancer 2010;46(9):1502-1513