Diyetle K Vitamini Alımı Bilişsel Performansı Etkiler mi?

K vitamini yağda çözünen bir vitamin olup doğada filokinon (K1) ve menakinon (K2) formlarında bulunmaktadır. Menadion (K3) formu ise sentetik analog olarak kullanılmaktadır. K vitamini, metabolizmada K vitaminine bağımlı proteinlerin karboksilasyonundan sorumludur. Genellikle kan koagülasyonü üzerine rolü olduğu bilinen K vitamininin günümüzde kardiyovasküler hastalıklar, osteoporoz, vasküler kalsifikasyon, kanser, diyabet ve glisemik kontrol ile de ilişkisi olduğu gösterilmiştir. Son yıllarda ise beyinde miyelinizasyonun yoğun olduğu bölgelerde Menakinon-4 (MK-4) formunda bulunduğu saptanmış ve bilişsel performans ile bazı nörodejeneratif hastalıkların patogenezinde rol alabileceği belirtilmiştir. Bu etkisini Gas-6 ve protein S gibi proteinler aracılığıyla veya nöronları oksidatif stres hasarına karşı koruyarak gösterdiği düşünülmektedir. Atriyal fibrilasyon (AF) hastalarının sıklıkla kullandığı antikoagülanların ve K vitamini antagonisti olmayan antikoagülanların bilişsel performans ve demans üzerine etkisi ise tartışmalıdır. Bu derleme makalede K vitamini ve antikoagülanların bilişsel performans üzerine etkileri ele alınmıştır.

Anahtar Kelimeler:

K vitamini, bilişsel performans, Alzheimer, antikoagülanlar

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