Kronik Miyeloid Lösemide İmatinib Mesilat Tedavisi

Amaç: Merkezimizde takip edilen ve imatinib tedavisi alan kronik miyeloid lösemi (KML) hastalarında tedavinin etkinliğini retrospektif olarak değerlendirmek.Gereç ve Yöntem: Çalışmaya klinik ve laboratuvar verileri tam olan 85 kronik evre KML hastası dahil edildi. Bu hastalar, interferon tedavisi sonrası hematolojik veya sitogenetik yanıt gözlenmeyen veya interferon tedavisine karşı intolerans gelişmiş veya birinci basamak tedavi olarak imatinib tedavisi almıştır.Bulgular: Kırk sekiz (% 56,47) hasta erkek, 37 (% 43,53) hasta kadındı. Tanı sırasındaki hastaların yaşlarının ortancası yaş 52 idi (19-79). Ortalama takip süresi 45 (12-158) aydı. İzlemde kronik faz hastalarının 6'sı blastik ve hızlandırılmış faza ilerlemiştir. İmatinib tedavisinin üçüncü ayında, 77 (% 90,59) hasta tam hematolojik yanıt aldı ve 85 (% 100) hasta 18 ayda tam hematolojik yanıt aldı. Çalışmamızda, uygun metafazlı (≥ 20) 78 hastanın sitogenetik verileri, tanı konulduktan sonraki ilk 18 ay içinde değerlendirildi. 18 ayın sonunda 78 hastanın 68'inde (% 87.18) tam sitogenetik yanıt vardı. Sonuç: İmatinib, KML hastaları tarafından iyi tolere edilir ve alternatif bir tedavi yöntemidir.

Anahtar Kelimeler:

Kronik miyeloid lösemi, tedavi, imatinib mesilat

Imatinib Mesylate Treatment in Chronic Myeloid Leukemia

Objective: To evaluate retrospectively the efficacy of treatment in chronic myeloid leukemia (CML) patients followed up in our center and receiving imatinib treatment.Materials and Methods: Eighty-five chronic phase CML patients with adequate clinical and laboratory data were included in the study. These patients had not given hematological or cytogenetic responses after interferon treatment, or had intolerance to IFN treatment or received imatinib treatment as a first-line treatment in late and early chronic stage patients.Results: Forty-eight (56.5%) patients were male and 37 (43.5%) of them were female. The median age at diagnosis was 52 years (19-79). The mean follow-up period was 45 (12-158) months. In the follow-up, 6 of the chronic phase patients progressed to blastic and accelerated phase. In the third month of imatinib treatment, 77 (90.6%) patients had complete hematologic response and 85 (100%) patients had full hematologic response at 18 months. In our study, cytogenetic data of 78 patients with adequate metaphase (≥ 20) could be evaluated within the first 18 months after the diagnosis was made. At the end of 18 months, 68 (87.2%) of 78 patients had complete cytogenetic response. Conclusion: Imatinib is well tolerated by CML patients and is a superior treatment alternative to other therapies other than bone marrow transplantation in achieving hematological and cytogenetic response.

Keywords:

Chronic myeloid leukemia, imatinib, treatment,

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