D Vitamini ve İn Vitro Fertilizasyon Sonuçları Üzerine Bir Derleme

D vitamininin kalsiyum-fosfor dengesinin sürdürülmesi ve kemik mineralizasyonundaki fonksiyonu oldukça iyi bilinse de üremeye etkisi tartışmalı bir konudur. Ulusal ve uluslararası çalışmalarda D vitamini eksikliğinin üreme çağındaki kadınlarda oldukça yaygın olduğu görülmektedir. D vitamininin seks steroid hormonlarıyla birlikte, kadın ve erkek üreme süreçlerinde etkili olduğu bilinmektedir. D vitamini reseptörlerinin ve vitamini metabolize eden enzimlerin üreme organlarında bulunması bu görüşü desteklemektedir. D vitamini eksikliği; infertilitenin etiyolojik faktörleri olan miyom, endometriozis, polikistik over, düşük ovarian reservi, düşük total sperm sayısı ve testesteron düzeyi ile ilişkilendirilmektedir. D vitamini eksikliğinin In Vitro Fertilizasyon sonuçları üzerinde etkilerini inceleyen 13 çalışmaya ulaşılmıştır. Ülkemizde bu konuda yapılan bir çalışmaya ulaşılmamıştır. Ayrıca bu alanda yapılmış iki adet sistematik derleme bulunmaktadır. Ancak tedavi öncesi rutin D vitamini takibi ve eksikliğine ilişkin tedavi ve bakımın yaygınlaştırılması için büyük ölçekli, kohort ve deneysel çalışmalara gereksinim vardır.

Anahtar Kelimeler:

D vitamini, infertilite, In Vitro Fertilizasyon

A Review on the Vitamin D and In Vitro Fertilization Outcomes

CThe effect on reproductive process of vitamin D is a controversial issue although the function on the bone mineralization and maintaining of the calcium-phosphorus balance of vitamin D is quite well-known. National and international studies show that vitamin D deficiency is quite common among women of reproductive age. Vitamin D with sex steroids are known to be effective in male and female reproductive processes. It supports the view that the presence of the reproductive tissue of Vitamin D receptors and enzymes that metabolize Vitamin D. In the literature, Vitamin D deficiency is associated with etiologic factors of infertility such as fibroids, endometriosis, polycystic ovary syndrome, low ovarian reserve, lower total sperm counts and testosterone levels. In this review, 13 research were achieved examining the impact on In Vitro Fertilization results of Vitamin D. In our country, it could not be reached to a study in this issue. Also, there are two systematic review in this issue. To routine monitoring of vitamin D and promoting of treatment and care in the lack of Vitamin D, large-scale, experimental and cohort studies are needed.

Keywords:

Vitamin D, infertility, In Vitro Fertilization,

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