Harun ÜLGER, Arzu YAY, Saim ÖZDAMAR

Teratogenıc effect of adrıamycın on septal heart development of early fetuses

Özofageal atrezi sıklıkla kardiyovasküler ve diğer malformasyonlar ile ilişkilidir. Bu çalışmada kalp gelişiminin sıçanlarda oluşturulan özofageal atrezi modelinde anormal olabileceği sınandı. Zaman kontrolu yapılarak çiftleştirilen gebe sıçanlara, gebeliğin 6-9. günlerinde 2 mg/kg adriamycin intraperitoneal olarak verildi. Kalp malformasyonları 13 günlük erken dönem fetuslarda mikroskopik olarak incelendi. Adriamycine maruz kalmış anne sıçanların embriyolarının (erken fetuslarını) çoğunda adriamycin rezorpsiyona neden olmuştu ve sadece yedi embriyo elde edilebildi. Kontrol fetuslar hiçbir kalp malformasyonuna sahip değilken adriamycine maruz kalmış yedi fetusun beşinde, özofagus atrezisi yanında interatriyal ve interventriküler septal defektler görüldü. Sonuç olarak, gebe sıçanlara adriamycin uygulaması embryolarda özofageal atrezi ve kalp malformasyonlarının oluşmasına sebep olur.

Erken dönem fetusların kalplerinde septal gelişim üzerine adriamycinin teratojenik etkisi

Esophageal atresia is often associated with cardiovas-cular and other malformations. The present study teststhe heart development which may be abnormal in therat model of esophageal atresia.Time-mated pregnant rats received 2 mg/kg adriamy-cin intraperitoneally on days 6-9 of gestation. The heartmalformations were investigated on day 13 of gestationunder the microscope in early term fetuses.Adriamycin caused resorption of most embryos (or early fetuses) and only seven embryos obtained from adriamycin received dams. Control fetuses had no heart malformations, whereas five of the seven fetuses exposed to adriamycin had interatrial and interven- tricular septal defects besides esophageal atresia. As a result, adriamycin administration to pregnant rats, results of esophageal atresia and cardiac malformations in embryos

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