ERKEN DÖNEM FETUSLARIN KALPLERİNDE SEPTAL GELİŞİM ÜZERİNE ADRİAMYCİN İNTERATOJENİK ETKİSİ

Özofageal atrezi sıklıkla kardiyovasküler ve diğer malformasyonlar ile ilişkilidir. Bu çalışmada kalp gelişiminin sıçanlarda oluşturulan özofageal atrezi modelinde anormal olabileceği sınandı. Zaman kontrolu yapılarak çiftleştirilen gebe sıçanlara, gebeliğin 6-9. günlerinde 2 mg/kg adriamycin intraperitoneal olarak verildi. Kalp malformasyonları 13 günlük erken dönem fetuslarda mikroskopik olarak incelendi. Adriamycine maruz kalmış anne sıçanların embriyolarının (erken fetuslarını) çoğunda adriamycin rezorpsiyona neden olmuştu ve sadece yedi embriyo elde edilebildi. Kontrol fetuslar hiçbir kalp malformasyonuna sahip değilken adriamycine maruz kalmış yedi fetusun beşinde, özofagus atrezisi yanında interatriyal ve interventriküler septal defektler görüldü. Sonuç olarak, gebe sıçanlara adriamycin uygulaması embryolarda özofageal atrezi ve kalp malformasyonlarının oluşmasına sebep olur.

Anahtar Kelimeler:

Adriamycin, kalp, kusurluluk, embriyo, gelişim

Teratogenic Effect of Adriamycin on Septal Development of Early Fetal Heart

Esophageal atresia is often associated with cardiovascular and other malformations. The present study tests the heart development which may be abnormal in the rat model of esophageal atresia. Time-mated pregnant rats received 2 mg/kg adriamycin intraperitoneally on days 6-9 of gestation. The heart malformations were investigated on day 13 of gestation under the microscope in early term fetuses. Adriamycin caused resorption of most embryos (or early fetuses) and only seven embryos obtained from adriamycin received dams. Control fetuses had no heart malformations, whereas five of the seven fetuses exposed to adriamycin had interatrial and interventricular septal defects besides esophageal atresia. As a result, adriamycin administration to pregnant rats, results of esophageal atresia and cardiac malformations in embryos.

Keywords:

Adriamycin, heart, malformation, embryo, development,

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