CİVAN PERÇEMİ (Achillea millefolium)’nin DİYABETİK SIÇANLARIN KARACİĞER DOKUSUNDAKİ ANTİOKSİDAN ENZİMLER ÜZERİNE KORUYUCU ETKİSİNİN ARAŞTIRILMASI

Amaç: Civan perçemi (CP) antioksidan, antibakteriyel,diüretik ve anti-inflamatuar etkilere sahiptir. Çalışmamızda, streptozotosinle diyabet oluşturulan sıçan karaciğer dokularında MDA seviyesi ve antioksidan enzimaktivitesi üzerine CP’nin koruyucu etkisi araştırıldı.Gereç ve Yöntem: Çalışmada 250-300 gr 40 adet erkekWistar albino sıçanlar kullanıldı. Kontrol grubu, Diyabetgrubu ve CP ile tedavi edilen diyabet grubu olmak üzere3 gruba ayrıldı. Sıçanlarda diyabet oluşturmak için tekdoz 60 mg/kg streptozotosin (STZ) intraperitonealolarak enjeksiyon yapıldı. Tedavi grubuna ise 6 haftasüre ile 250 mg/kg/gün CP verildi. Deneyin sonundabütün hayvanlar sakrifiye edildi.Bulgular: Çalışma sonucunda streptozotosinle diyabetoluşturulmuş sıçanlarda kontrol grubu ile karşılaştırıldıklarında diyabet oluşturulan sıçanların karaciğerdokusundaki lipit peroksidasyon ürününde (MDA) veSOD enzim aktivitesinde, CAT ve GSH düzeylerindeistatistiksel olarak anlamlı derecede fark olduğu gözlendi (p

INVESTIGATION OF THE PROTECTIVE EFFECT OF CIVAN PERCEMI (Achillea millefolium) ON ANTIOXIDANT ENZYMES IN LIVER TISSUE OF DIABETIC RATS

Objective: Archilia millefolium (CP) has antioxidant, antibacterial, diuretic and anti-inflammatory effects. In this study, the protective effect of CP on MDA level and antioxidant enzyme activity in rat liver tissues induced by streptozotocin was investigated. Materials and Methods: Forty male Wistar albino rats were used in the study. The control group was divided into three groups: Diabetes group and CP treated diabetes group. A single dose of 60 mg/kg streptozotocin (STZ) was injected intraperitoneally to induce diabetes in rats. The treatment group received 250 mg/kg / day CP for 6 weeks. At the end of the experiment, all animals were sacrificed. Results: As a result of the study, it was observed that there was a statistically significant difference in lipid peroxidation product (MDA) and SOD enzyme activity, CAT and GSH levels in liver tissue of diabetic rats compared with control group in streptozotocin-induced diabetic rats (p

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