Dejeneratil artritlerde intraartikuler olarak uygulanan hyaluronik asit (HA) ve metil prednisolon asetat (MPA)tedavilerinin etkilerini ara$tlrmak i9in deneysel bir 9all!~ma yaplldl. 40 adet erkek raM sag arka diz eklemlerii9ine 0.2 ml %1'lik lormalin veriierek deneysel artrit olu$turuldu. IIa9 verilmesinden bir hafta sonra 10 rat61dunJlerek artrilin olu$tugu histopatolojik olarak be/iriendi. Kalan 30 rat 3 gruba aynldl. Birinci gruba 0.05 mlintraartikiiler HA (HA grubu), ikinci gruba 0.05 ml intraartikLiler MPA (MPA grubu) verildi. 09uncu gruba iseintraartikiiler 0.05 ml serum lizyolojik venlerek kontrol grubu olu$turuldu. Tedaviler artrit olu$turulduktan sonra7. Gun, 14. Gun ve 21. gun uygulandl. Uygulanan bu tedavilerin bitiminden 15 giin sonra rat/ar 61duriildu vealman omekler, histopatolojik olarak incelendi.Yapilan incelemede; MPA grubunda klkmjak iyile$mesi a9lsmdan kontrol grubuna g6re anlaml! farkbulunamadl (p>0.05). HA grubunda ise klklrdak iyile$mesi MPA ve kontrol grubuna gore anlamli olarakyiiksek bulundu (p<0.05).Intraartikiiler artrit tedavisinde klklrdak dokusu uzerine olumlu etkilerinden dolaYI HA'in MPA 'a g6re dahayararll oldugu sonucuna vanldl.Anahtar kelimeler: Oeneysel artrit, klklrdak, hyaluronik asit, metil prednisolon asetat.SUMMARYThis experimental study was performed to determine the effects of intraarticular hyaluronic acid (HA) andmethyl prednisolone acetate (MPA) in degenerative osteoarthritis. 0.2 ml 1% formaline were injected to theposterior right knee joints of 40 male rats. One week after the injections. 10 rats were killed and arthritis wasdetermined histopathologically. The remained 30 rats were divided to three groups. First group receivedintraarticularly 0.05 ml HA (HA group), second group 005 ml MPA (MPA group) and third group 0.05 ml salineas controls. The injections were performed at 7., 14. and 21- days after the arthritis. 15 days after the end ofthese treatments, rats were killed and sections were examined histopathologically.There was no significantly difference in cartilage healing between MPA and control groups (p>0.05). Howevercartilage healing was significantly high in HA group compared to MPA and control groups (p<0.05).It was concluded that HA is more useful than MPA in the treatment of arthritis intraarticularfy because of itspositive effects on cartilage tissue.Key words: Experimental arthritis, cartilage, hyaluronic acid, methyl prednisolone acetate.