Müjgan TEK, Fatma AYERDEN EBİNÇ, Aysun AYBAL KUTLUGUN, Fatma KAPLAN EFE, Mehmet Serkan ÇETİN, Sevaş ÇELEBİ, Berkten BERKALP

Hipertansif Hastalarda Reverse-dipper Kan Basıncı ile Nötrofil Lenfosit Oranı Arasındaki İlişki

Revers dipper hipertansiyon ve nötrofil/lenfosit oranı (NLR), kardiyovasküler risk öngördürücüsü olarak araştırılmaktadır. NLR ve diğer sirkadyen kan basıncı paternleri arasındaki ilişki gösterilmiştir. Bu çalışmanın amacı hipertansif hastalarda nötrofil lenfosit oranı ile revers dipper kan basıncı paterni arasındaki ilişkiyi değerlendirmektir. Çalışmaya 144 (66 erkek, 78 kadın) hipertansif hasta alındı. Kan basıncı paternleri 24 saat ambulatuar kan basıncı ile değerlendirildi. Nötrofil lenfosit oranı, nötrofil sayısı lenfosit sayısına bölünerek ölçüldü. Revers dipper hipertansiyonlularda dipper hipertansiyonlulara göre nötrofil lenfosit oranında anlamlı artış vardı. (sırasıyla 2.36±1,68 ve 1,81±0,69, p=0,040 ). Nötrofil lenfosit oranı ile sistolik (r=-0,193;p=0.021 ve diyastolik ( r=-0,160; p=0,057) kan basıncı düşme oranları arasında negatif korelasyon vardı. Çalışmamız NLR ve revers dipper patern arasında olası bir ilişki sunmaktadır ancak nötrofil lenfosit oranını, revers dipper paternin bağımsız öngörücüsü olarak rapor etmek için daha ileri çalışmalar gereklidir.

Anahtar Kelimeler:

Nötrofil lenfosit oranı, revers dipper

The Relation Between Blood Pressure Reverse-Dipping and Neutrophil to Lymphocyte Ratio in Hypertensive Patients

Reverse dipper hypertension and neutrophil to lymphocyte ratio (NLR) has been investigated as a predictor for cardiovascular risk. The relationship between NLR and other circadien blood pressure (BP) patterns has been showed. The aim of this study was to investigate the relation between NLR and BP reverse dipper pattern in patients with hypertension. 144 hypertensive patients (66 males, 78 females) were enrolled the study. BP patterns were evaluated with 24-h ambulatory BP monitoring (ABPM). Baseline NLR was measured by dividing neutrophil count to lymhocyte count. There was significantly increased NLR in reverse dippers (2,36±1,68 ) than dippers (1,81±0,69) of hypertension (p=0,040 ). NLR was negatively correlated with the decline rate of nocturnal systolic BP(r=-0,193;p=0.021) and diastolic BP( r=-0,160; p=0,057). Our study provides a possible association between NLR and reverse dipper pattern, but to report NLR as an independent predictor of reverse dipper pattern further studies are required.

Keywords:

NLR, reverse - dipper,

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