Clinical Significance of Atypical Squamous Cells in Which High Grade Lesions Cannot Be Excluded; Experience of a Tertiary Hospital in Anatolia

The primary aim of our study was to evaluate the histological results of patients diagnosed with atypical squamous cells, cannot exclude high-grade lesion (ASC-H) by cervical cytology and to reveal the clinical importance of ASC-H.Twenty thousand one hundred sixty three cervicovaginal smears were evaluated. Seventy six (0.376 %) patients were diagnosed as ASC-H. Files of patients diagnosed with ASC-H were retrospectively reviewed. We referred patients who were diagnosed as ASC-H according to the Bethesda classification system after cervicovaginal smear for colposcopic examination. İf it is necessary, cervical biopsy, endocervical and endometrial curettage were performed by the colposcopy guide. Clinicopathological features of the patients were examined and recorded. Smear results of 20163 patients reviewed. Abnormal cytological results were found in 1188 (5.8%) patients. The abnormal cytological results were ASC-H in 76 (0.37% ) patients. Abnormal cervical dysplasia was detected in 36 (47.3%) of 76 patients diagnosed as ASC-H. Twenty (20/76-26.3%) of these abnormal lesions were high-grade cervical intraepithelial neoplasia (CIN2 / 3), 12 (12/76-15.7%) of them were low-grade cervical intraepithelial neoplasia (CIN 1) and 4 (4 /76-5%) of them were cervical carcinoma. ASC-H is a diagnosis with significant association with precancerous and cancerous lesions. Therefore, further evaluation of ASC-H patients should be performed with the necessary care and attention

Yu ksek Dereceli Lezyonların Dışlanamayacag ı Atipik Skuamo z Hu crelerin Klinik Ö nemi; Anadolu’daki Bir Ü çu ncu l Hastanenin Deneyimi

Çalışmamızın öncelikli amacı servikal sitolojide yüksek dereceli skuamöz lezyonların dışlanamadığı atipik skuamöz hücre (ASC-H) tanısı almış hastaların histolojik sonuçlarının değerlendirilmesi ve bu durumun klinik öneminin ortaya çıkarılmasıdır. Yirmibin yüzaltmışüç hastanın smear sonuçları değerlendirildi. Yetmiş altı (0.376 %) hastada ASC-H tanısı kondu. ASCH tanısı konan hastaların dosyaları retrospektif olarak gözden geçirildi. ASCH tanısı konan tüm hastalara kolposkopik muayene işlemi yapıldı. Kolposkopik muayenede gerekli görülen hastalara eksizyonel işlemler ile servikal ve endoservikal biyopsi işlemleri uygulandı. Hastaların klinik patolojik bilgileri dosyalarından incelenip toplandı. Gözden geçirilen 20163 smear sonucunda 1188 (5.8%) hastada servikal anormal sitoloji tespit edildi. Bu anormal servikal sitolojilerin 76 tanesinde ASCH (0.37% ) tespit edildi. ASCH tanısı alan 76 hastanın 36 (47.3%) tanesinde anormal servikal displazi tespit edildi. Bunlarında 20 (20/76-26.3%) tanesinde yüksek dereceli servikal intraepitelyal neoplazi (CIN2-3) ,12 (12/76-15.7%) tanesinde düşük dereceli servikal intraepitelyal neoplazi(CIN1) ve 4 (4 /76-5%) tanesinde servikal invazif kanser tespit edildi. ASCH tanısı önemli oranda prekanseröz ve kanseröz lezyonlarla ilişkilidir. Bu nedenle ASCH hastalarının yönetiminde ileri değerlendirme yapılırken gerekli özen ve dikkat sağlanmalıdır.

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