Merve Iseri Nepesov, Omer Kilic, Ener Cagri Dinleyici, Murat Yagci

Enteroviru s ve Human Herpes Viru s 6’nın Birlikte Saptandıg ı Menenjit Olgusu; Hangisi Gerçek Etken?

Viral menenjitler çoğunlukla kendi kendini sınırlayan merkezi sinir sistemi enfeksiyonları olup polimeraz zincir reaksiyonu (PZR) yönteminin rutin klinik uygulamada giderek artan oranda kullanılmaya başlanmasıyla tanı şansı artmıştır. Virüsler, menenjit etiyolojisinde giderek artan oranda bildirilmekte, non polio enterovirüsler en sık viral menenjit etkeni olarak tanımlanmaktadır. Bir diğer menenjit/ensefalit etkeni olarak bilinen HHV-6’ın (human herpes virüs 6) ise kromozom yapısına entegre olup genetik geçişe yol açabilmesi gerçek merkezi sinir sistemi enfeksiyonu etkeni olup olmamasını tartışmalı hale getirmiştir. Aşağıda ateş ve beslenememe yakınmaları ile getirilen 42 günlük hastada Enterovirüs ve Human Herpesvirüs-6 (HHV-6) ilişkili viral menenjit literatür verileri ışığında tartışılmıştır.

A Case of Meningitis İ nvolving Both Enterovirus and Human Herpes Virus 6; Which is the Real Causative Agent?

Being mostly a self-limiting central nervous system infection, viral meningitis can now be diagnosed more easily with theincreasing use of polymerase chain reaction method in routine clinical practice. Viruses are being reported in the etiology ofmeningitis at increasingly higher rates, non-polio enteroviruses being the most common causative agent of viral meningitis. Theability of human herpes virus 6, which is known to be another causative agent for meningitis/encephalitis, to integrate into thechromosomal structure and lead to a genetic transition makes it debatable whether it is a real cause of central nervous systeminfections. This article discusses, also referring to the literature, a case of viral meningitis associated with enterovirus and humanherpes virus-6 detected in a 42-day old patient who had fever and poor feeding.

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