Cerrahi Tedavi Sonrası Adjuvan Kemoterapi Alan ve Almayan Evre II Kolon Kanserli Hastaların Klinik ve Patolojik Özelliklerinin Karşılaştırılması

Bu çalışmanın amacı, evre II kolon kanseri nedeniyle postoperatif adjuvan kemoterapi alan ve almayan hastalar arasındaki klinik ve patolojik özellikleri ve sağkalımı karşılaştırmaktır. Evre II kolon kanseri nedeniyle opere edilen ve kliniğimizde takip edilen hastaların kayıtları retrospektif olarak incelendi. Hastalar yaş, cinsiyet, tümör boyutu ve evresi, alınan lenf nodu sayısı, lenfovasküler invazyon varlığı, tümör lokalizasyonu, tanı sırasındaki bağırsak perforasyonu veya obstrüksiyon bulguları, hastalıksız ve genel sağkalım oranları gibi çeşitli klinikopatolojik özellikler bakımından karşılaştırıldı. Evre II kolon kanseri olan toplam 57 hasta çalışma kapsamına alındı. Toplam 43 (% 75,4) hastaya ameliyat sonrası adjuvan kemoterapi, kalan 14 hastaya (% 24,6) sadece küratif cerrahi uygulandı. . T4 lezyonlu (n = 26) hastaların 23'ünde (% 53,5) postoperatif adjuvan kemoterapi uygulandı. T4 lezyon varlığının rekürrens üzerine etkisi istatiksel olarak anlamlı bulundu (p = 0.015).Ancak genel sağkalıma etkisi saptanmadı (p = 0.89). Kemoterapi alan hastaların klinik veya patolojik özellikleri, sağkalım veya rekürrens ile anlamlı şekilde ilişkili bulunmamıştır. . Evre II kolon kanserli hastaların tedavi alıp almamasına bireysel özelliklerin değerlendirilmesiyle karar verilmelidir.

Anahtar Kelimeler:

Evre II Kolon Kanser, Postoperatif adjuvan kemoterapi

Comparison of Clinical and Pathologic Outcomes and Between Patients With Stage II Colon Cancer Who Did And Did Not Receive Postoperative Adjuvant Chemotherapy

The aim of this study is to compare clinical and pathologic outcomes and survival between patients with stage II colon cancer who did and did not receive postoperative adjuvant chemotherapy. A retrospective examination was made of the records of patients with stage II colon cancer who underwent surgery and followed up in our clinic. Patients were compared with regards to several clinicopathological features such as age, sex, tumor size and stage, number of nodes retrieved, the presence of lymphovascular invasion, tumor localization, signs of intestinal perforation or obstruction at presentation, disease-free and overall survival rates. A total of 57 patients with stage II colon cancer were included in the study. Overall 43 (%75, 4) patients received postoperative adjuvant chemotherapy and the remainder [n=14 (%24,6)] underwent curative surgery alone. Of the patients with a diagnosis of T4 lesion (n=26), 23 (%53, 5) received postoperative adjuvant chemotherapy. The presence of T4 lesion was found to be significantly associated with recurrence (p: 0.015) but not with overall survival (p: 0, 89). Neither the clinical nor the pathologic features of patients who received chemotherapy were significantly associated with survival or recurrence. Patients with stage II colon cancer should be treated with the treatment of individual characteristics.

Keywords:

Stage II colon cancer,

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