Cafer YILDIRIM, ŞULE AYDIN, Fatma Sultan KILIÇ

“Euterpe Olerecea” nın Antioksidan ve Öğrenme –Bellek Üzerindeki Etkileri

Öğrenme ve bellek bozuklukları; yaşam kalitesini olumsuz yönde etkileyen birçok hastalıkla primer veya sekonder olarak ilişkilidir. Öğrenme ve bellek, çevreden gelen uyaranların değerlendirilmesi ve uygun davranışların geliştirilmesi gibi temel zihinsel süreçleri düzenler. İnsanlar gerçekleştirdikleri her işlemde bilinçli veya bilinçsiz olarak bellek işlevlerine başvururlar. Kognitif bozukluklar başta demans ve Alzheimer hastalığı olmak üzere; şizofreni, depresyon, anksiyete, uyku bozuklukları, dikkat eksikliği ve hiperaktivite, madde bağımlılığı gibi birçok durumla ilişkilendirilmektedir. Alzheimer hastalığının erken dönemlerinde ortaya çıkan kognitif bozulmalar, episodik bellek ve uzamsal oryantasyon yeteneğinde gerileme ile başlar. Dünya Sağlık Örgütü verilerine göre Alzheimer hastalığı dünya çapında 47. 5 milyon kişi etkilemişken her yıl bu sayıya 7. 7 milyon yeni vaka eklenmektedir. Son yıllarda çok sayıda çalışmada, Açai bitkisi ekstraktı olarak da bilinen Euterpe olerecea’nın Parkinson ve Alzheimer gibi nörodejeneratif hastalıkların riskini azalttığı, serebral kortekste %48 civarında, hipokampusta yaklaşık %64 ve serebellumda yaklaşık %72 olmak üzere nöroprotektif etki ve beyin hücrelerinde oluşan inflamasyon ve oksidatif hasarın azaltılmasında başarı sağladığı gösterilmiştir.

Anahtar Kelimeler:

Euterpe olerecea, öğrenme ve bellek, antioksidan etki

The Effects of Euterpe Olerecea on Learning and Memory and Antioxidant Parameters

Learning and memory disorders are associated primarily or secondarily with many diseases that adversely affect the quality of life. Learning and memory regulates main cognitive processes evaluating stimulus from environmental and improving suitable behaviours. People consciously or unconsciously apply to memory functions in all processes they performed. Cognitive disorders are associated with mainly dementia and Alzheimer’s disease, and also with many conditions such as schizophrenia, depression, anxiety, insomnia, attention deficit and hyperactivity disorder. Cognitive disorders which arise at early stages of Alzheimer’s disease introduce as regression in the episodic memory and spatial orientation skills. According to the data of World Health Organization ; 47.5 million people have dementia worldwide and 7.7 million new cases ocur every year. Some studies show that Euterpe olerecea, known as extract of Açai plant, decreases the risk of neurodejenerative diseases such as Parkinson’s disease and Alzheimer’s disease, exerted neuroprotective effects on cerebral cortex around 48%, hippocampus about 64%, and cerebellum about 72% and was reported to be successful at reducing inflammation and oxidative damage in brain.

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