Pulmoner emboli şüphesi olan hastalarda siklofilin A ve VAP-1’in tanısal değeri

Amaç: Bu çalışmanın amacı endotel hasarı sonucu trombosit aktivasyonu ve kümeleşmesinin patofizyolojisinde rol oynadığı bilinen pulmoner emboli (PE) hastalığında; endotel disfonksiyonu, platelet adezyonu ve arterial trombüs ile ilişkelendirilen siklofilin A (CYPA) ve vasküler adezyon protein- 1 (VAP-1) adlı biyokimyasal belirteçlerin tanısal değerini araştırmaktır.Gereç ve Yöntem: Prospektif olarak yapılan bu klinik çalışmada acil servise akut PE şüphesi ile başvurarak çalışmaya alınan ve spiral bilgisayarlı tomografi anjiografi ile PE varlığı değerlendirilen 165 hastanın serum CYPA ve VAP-1 düzeyi ölçüldü. Bilgisayarlı tomografi sonuçlarına göre, PE (+) ve PE (-) olarak 2 gruba ayrılan bu hastaların ölçülen CYPA ve VAP-1 düzeyleri birbirleriyle karşılaştırıldı.Bulgular: Her iki grup ölçümleri birbiriyle karşılaştırıldığında VAP-1 düzeyi bakımından gruplar arası fark istatistiksel anlamlı bulunurken (p=0.0001), CYPA düzeyinin bakımından bu fark istatistiksel olarak anlamlı değildi. (p=0.381). Sonuç: Akut PE’de serum VAP-1 düzeyinin tanısal olarak kullanılabileceği tespit edilmiştir. Serum CYPA düzeyinin ise akut PE’de tanısal değeri bulunmamaktadır.

Anahtar Kelimeler:

Pulmoner emboli, siklofilin A, VAP-1

The diagnostic value of cyclophilin A and VAP-1 in patients with suspected pulmonary embolism

Aim: To investigate the diagnostic value of the biochemical markers cyclophilin A (CYPA) and VAP-1, associated with endothelial dysfunction, platelet adhesion, and arterial thrombus in pulmonary embolism (PE), in whose pathophysiology platelet activation and aggregation resulting from endothelial damage are known to be involved. Material and Method: Serum CYPA and VAP-1 levels of 165 patients presenting to the emergency department with suspected acute PE and with presence of PE investigated at spiral computerized tomography angiography were measured in this prospective clinical study. These patients were assigned into two groups, PE (+) and PE (-), based on the tomography results, and their CYPA and VAP-1 levels were then compared. Results: Comparison of the two groups’ measurements revealed a significant difference in terms of VAP-1 levels (p=0.0001), but none for CYPA (p=0.381). Conclusion: Diagnostic value was determined for serum VAP-1 levels in acute PE, but CYPA levels are of no such value.

Keywords:

Pulmonary embolism VAP-1, cyclophilin A, VAP-1,

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