Nurullah ÇELİK, Emine ÇAMTOSUN, İsmail DÜNDAR

Prematür adrenarşli olgularda hematolojik parametrelerin değerlendirilmesi

Amaç: Obez olmayan prematür adrenarşlı olgularda hematolojik parametreleri değerlendirmek ve bu parametrelerin androjenlerle olan korelasyonlarını göstermektir. Gereç ve Yöntem: Bu çalışma bir vaka kontrol çalışması olup hasta dosyaları retrospektif olarak araştırıldı. PA tanılı 6-9 yaş arası prepubertal 44 çocuk ile herhangi bir sistemik hastalığı olmayan yaş ve cinsiyetleri benzer 45 çocuk çalışmaya dahil edildi. Gruplar arası hemogram parametreleri karşılaştırıldı, androjen düzeyleri ile olan korelasyonları değerlendirildi. Bulgular: Vaka grubunda yaş ortalaması 7,61±1 yıl iken kontrol grubunda 7,42±0,9 idi, (p>0,05). Vaka ve kontrol grubu karşılaştırıldığında eritrosit sayıları (5,07±0,22, 4,87±0,31; p<0,05), Hemoglobin düzeyleri (Hgb) (13,77±0,79, 12,89±0,84; p<0,05), ortalama eritrosit hacmi (81,83±3,73, 79,99±3,74; p<0,05) ve eritrosit dağılım aralığı (12,71±1,80, 13,56±0,66; p<0,05) farklı idi. Ayrıca dehidroepiandrosteron-sülfat düzeyi ile Hgb düzeyi arasında pozitif bir korelasyon vardı (r=0,27; p=0,03).Sonuç: Prematür adrenarşlı olgularda daha yüksek Hgb ve eritrosit düzeyleri bu olgularda görülen androjen biyosentez basamaklarında erken hızlanmış fonksiyonel aktivite ile ilişkili olabilir. Bu konuda daha geniş vaka serili çalışmalara ihtiyaç vardır.

Anahtar Kelimeler:

Prematür adrenarş, hemoglobin, eritrosit, dehidroepiandrosteron sülfat

Evaluation of hematological parameters in cases with premature adrenarche

Aim: To investigate hematological parameters in cases with non-obese premature adrenarche (PA) and to evaluate the correlations between this parameters and androgen levelsMaterial and Method: The study was a case-control study and the files of the patients was analysed retrospectively. Forty-four children with PA aged 6-9 years and their age and sex matched healthy controls (n=45) were included for the study. Hematological parameters between groups were compared and the correlations between this parameters and androgen levels were evaluated.Results: The mean ages of the case (7.61±1) and control (7.42±0.9) groups were similar (p>0.05). When we compared between case and control groups, mean erythrocyte count (5.07±0.22, 4.87±0.31; p<0.05), hemoglobin (Hgb) levels (13.77±0.79, 12.89±0.84; p<0.05), mean corpuscular volume (81.83±3.73, 79.99±3.74; p<0.05) and red cell distribution wide (12.71±1.80, 13.56±0.66; p<0.05) were different. On the other hand, dehydroepiandrosterone sulfate level was positively correlated with Hgb levels (r=0.27; p=0.03). Conclusion: Higher Hgb and erythrocyte levels in cases with PA may be partially explained with increased early and accelerated function in the androgen biosynthetic steps in this patients. Larger comprehensive studies with an increased number of cases in each group are needed to explore the alterations. early and accelerated function in the androgen biosynthetic steps.

Keywords:

Premature adrenarche, erythrocyte, hemoglobin, dehydroepiandrosterone sulfate,

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