PFAPAsendromunda yeni öngörücü parametreler: nötrofil-lenfosit oranı ve trombosit-lenfosit oranı

Amaç: Bu çalışmada PFAPA sendromu tanısı konulan hastalar ile sağlıklı bireyler yeni inflamasyon belirteçlerinden olannötrofil-lenfosit oranı (NLO) ve trombosit-lenfosit oranı (TLO) bakımından karşılaştırıldı.Gereç ve Yöntem: Çalışmaya PFAPA sendromu tanısı konulmuş 30 hasta (Pf grubu) (16 erkek, 14 kadın; ort. yaş 3,33; dağılım1-21 yıl) ile 30 sağlıklı birey (15 erkek, 15 kadın; ort. yaş 4,01 yıl; dağılım 1-23 yıl) (kontrol grubu) dahil edildi. Her iki grubunhematolojik parametreleri istatiksel olarak karşılaştırıldı. Nötrofil, lenfosit, trombosit değerleri ile NLO ve TLO oranlarıkullanıldı.Bulgular: Nötrofil, lenfosit ve trombosit değerleri karşılaştırıldığında Pf ve kontrol grubu arasında bir fark gözlenmedi(p>0.05). NLO oranları karşılaştırıldığında Pf grubunda (p=0,012) istatiksel olarak anlamlı yükseklik saptandı. TLO oranlarıkarşılaştırıldığında ise istatiksel fark gözlenmedi (p=0,117).Sonuç: PFAPA sendromu tanısı genellikle klinik olarak konulmaktadır. Ancak tanısı zor konan vakalarda NLO oranı birlaboratuvar bulgusu olarak yardımcı olabilir.

New predictive parameters of PFAPA syndrome: neutrophil to lymphocyte ratio and platelet to lymphocyte ratio

Objective: In this study, neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR), which are new markers of inflammation, were compared between patients diagnosed with PFAPA syndrome and healthy individuals. Material and Method: Thirty patients (Pf group) (16 males, 14 females; mean age 3.33; range 1-21 years) diagnosed with PFAPA syndrome and 30 healthy individuals (15 males, 15 females; mean age 4.01 years; range 1-23 years) (control group) were included in the study. Hematologic parameters of both groups were compared statistically. Neutrophil, lymphocyte, platelet values and NLR and TLO ratios were used for comparison. Results: When neutrophil, lymphocyte and platelet values were compared, no difference was observed between Pf and control groups(p> 0.05). When the NLR ratios were compared, a statistically significant increase was detected in the Pf group (p = 0.012). When the PLR ratios were compared, no statistical difference was observed (p = 0.117). Conclusion: PFAPA syndrome is usually diagnosed clinically. However, in diagnosis of difficult clinical cases, the rate of NLR may be helpful as a laboratory finding.

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