Turgut KÜLTÜR, Aydın ÇİFCİ, Ahmet İNANIR

Kronik böbrek hastalığında kemik-mineral metabolizması bozuklukları (renal osteodistrofi) ve tedavi yaklaşımı

Kronik böbrek hastalığında devam eden parankim kaybı nedeniyle böbrek fonksiyonları azaldıkça kemik-mineral metabolizmasında bozulmalar olmaktadır. Bu durumu oluşturan temel neden sekonder hiperparatiroididir ve bu tabloya da renal osteodistrofi denilmektedir. Bu tabloda vitamin D eksikliği, fosfat retansiyonu, hipokalsemi, sekonder hiperparatiroidinin oluşturduğu mineral metabolizması bozukluğu, kemik yapısında bozulma ile beraber vasküler ve/veya yumuşak doku kalsifikasyonları, metastatik kalsifikasyonlar söz konusudur. Renal osteodistrofi kronik böbrek hastalarında hem yaşam kalitesini düşürmesi hem de yaşam süresini kısaltıyor olması nedeniyle önem arz etmektedir.

Anahtar Kelimeler:

Kronik böbrek hastalığı, kemik mineral metobolizması bozuklukları

Bone-minerale metabolism disorders (renal osteodystrophy) in chronic kidney disease and treatment approach

When renal functions decrease with the ongoing parenchymal loss in chronic renal disease impairement of bone- mineral metabolism occurs. Secondary hyperparathyroidism is there all cause of this situation, and this case is called renal osteodystrophia. In this disease there are vitamin D deficiency, phosphate retension, hypocalcemia, mineral metabolism impairement due to secondary hyperparathyroidism, disturbance in the bone structure and vascular and/or soft tissue calcification, metastatic calcifications. Renal osteodystrophia is important in chronic kidney disease patients as it not only disturbs the quality of life of the patients but also decreases the survey of the patients.

Keywords:

Chronic kidney disease, bone mineral metabolism disorders,

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