Tülay OMMA, Ahmet OMMA, Sevinç Can SANDIKÇI, Yaşar KARAASLAN

The prevalence of anti-cyclic citrullinated peptide (anti-CCP) antibodies in patients with thyroid autoimmunity

Amaç: Anti-CCP antikorları romatoid artritin (RA) tanı koydurucu belirteçlerinden bir tanesi olmakla birlikte sistemik lupus eritematozus (SLE), primer Sjögren sendromu (pSS) gibi diğer hastalıklarda da saptanabilmektedir. Yetişkinlerde tiroid otoimmünitesi (TO) ve anti-CCP pozitifliğiyle ilgili günümüze kadar herhangi bir veri yayınlanmamıştır. Biz bu çalışmada yetişkin TO olan hastalarda anti-CCP pozitifliği yaygınlığını saptamayı amaçladık. Yöntem ve Gereçler: Ocak 2010-Ekim 2014 tarihleri arasında anti-CCP, RF ve anti-tiroid peroksidoz (anti-TPO) ve/veya TSH reseptör antikoru (TRAb) istenen 1282 hastanın kayıtları tıbbi kayıt sisteminden retrospektif olarak incelendi. TO, tanısı tiroid otoantikorlarının normal değerlerinin üst sınırının üzerinde saptanması ile kondu. RF ve anti-CCP pozitifliği değerler normal aralığın üzerinde olduğu zaman düşünüldü. Bulgular: TO olan grupta,TPO-Ab, TRAb, CCP ve RF pozitifliği sırasıyla 332 (%99), 7 (%2), 44 (%13), ve 78 (%23) olarak saptandı. TO olmayan grupta 70 kişide Anti-CCP pozitifliği (%7.4) ve 378 kişide RF pozitifliği (%20) saptandı. Anti-CCP pozitiflik oranı TO olan grupta TO olmayan gruba göre anlamlı olarak daha yüksek saptandı (%13 vs.%7.4, p

Tiroid otoimmünitesi olan hastalarda anti-siklik sitrülinlenmiş peptit (a[nti-CCP) antikor yaygınlığı

Aim: Anti-cyclic citrullinated peptide (anti-CCP) antibodies are one of the diagnostic markers of rheumatoid arthritis (RA), but can also be found in other diseases such as systemic lupus erythematosus, primary Sjogren's syndrome. So far, there has been no data available which identified prevalence of anti-CCP in patients with thyroid autoimmunity (TA). We aimed to identify anti-CCP prevalence in adult patients with TA.Material and Methods: We reviewed retrospectively medical records of 1282 patients including TPO-Ab, TRAb, rheumatoid factor (RF), anti-CCP antibodies in the computer database between the dates of January 2010 and October 2014. TA diagnosis was made if thyroid autoantibodies were higher than the upper limit of normal. Anti-CCP and RF positivity were considered if the values exceeded the upper limit of normal. Patients with or without TA were compared in terms of the prevalence of anti-CCP antibodies.Results:In group with TA, TPO-Ab, TRAb, CCP, and RF were detected in 332 (99%), 7 (2%), 44 (13%), and 78 (23%) patients respectively. In group without TA, CCP was detected in 70 patients (7.4%), and RF was detected in 378 (20%) patients. The positive rates of anti-CCP were significantly higher in patients with TA than the patients without TA (13% vs.7.4%, p

PDF

___

Schellekens GA, Visser H, de Jong BA, et al. The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide. Arthritis Rheum. 2000 Jan;43(1):155-63.
Kakumanu P, Sobel ES, Narain S, et al. Citrulline dependence of anti-cyclic citrullinated peptide antibodies in systemic lupus erythematosus as a marker of deforming/erosive arthritis. J Rheumatol. 2009 Dec;36(12):2682-90.
Ingegnoli F, Galbiati V, Zeni S, et al. Use of antibodies recognizing cyclic citrullinated peptide in the differentialdiagnosis of joint involvement in systemic sclerosis. Clin Rheumatol. 2007 Apr;26(4):510-4.
Gottenberg JE, Mignot S, Nicaise-Rolland P, et al. Prevalence of anti- cyclic citrullinated peptide and anti-keratin antibodies in patients with primary Sjögren's syndrome. Ann Rheum Dis. 2005 Jan;64(1):114-7.
Lee AN, Beck CE, Hall M. Rheumatoid factor and anti-CCP antibodies in rheumatoid arthritis: a review. Clin Lab Sci. 2008; 21 (1):15-18
Rapoport B, Chazenbalk GD, Jaume JC, McLachlan SM. The thyrotropin (TSH) receptor: interaction with TSH and autoantibodies. Endocr Rev 19: 673-716.
Punzi L, Betterle C. Chronic autoimmune thyroiditis and rheumatic manifestations. Joint Bone Spine 2004; 71(4):275-83.
Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham COIII, et al. 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/ European League Against Rheumatism collaborative initiative. Ann Rheum Dis 2010;69(9):1580-8.
McLeod DS, Cooper DS. The incidence and prevalence of thyroid autoimmunity. Endocrine 2012;42:252-265
El-Sherif WT, El Gendi SS, Ashmawy MM, Ahmed HM, Salama MM. Thyroid disorders and autoantibodies in systemic lupus erythematosus and rheumatoid arthritis patients. Egypt J Immunol 2004; 11(2):81-90.
Segni M, Pucarelli I, Truglia S, Turriziani I, Serafinelli C, Conti F. High Prevalence of Antinuclear Antibodies in Children with Thyroid Autoimmunity. J Immunol Res. 2014:150239.
Benhatchi K, Jochmanová I, Habalová V, et al. CTLA4 exon1 A49G polymorphism in Slovak patients with rheumatoid arthritis and Hashimoto thyroiditis-results and the review of literature. Clin Rheumatol. 2011; 30: 1319-1324.
Eberhard BA, Laxer RM, Eddy AA, Silverman ED. Presence of thyroid abnormalities in children with systemic lupus erythematosus. J Pediatr. 1991; 119(2):277-9.
Punzi L, Schiavon F, Ramonda R, Cavasin F, Ruffatti A, Todesco S. Anti- thyroid antibody in synovial fluid as a revealing feature of seronegative autoimmune thyroiditis. Clin Rheumatol 1991; 10(2):181-3.
Segni M, Pucarelli I, Truglia S, Turriziani I, Serafinelli C, Conti F. High Prevalence of Antinuclear Antibodies in Children with Thyroid Autoimmunity. J Immunol Res. 2014;2014:150239.