Valproic acid-induced neutropenia

Valproik asit, önemli antikonvülzan ajanlardan biri olmakla beraber ciddi yan etkilere sa-hiptir. Nötropeni bunlardan biridir. Bir yaşında kız hastanın, kontrol muayenesi için başvurduğu sırada yapılan tam kan sayımında, nötropeni saptandı. Yapılan bazı spesifik tanı testlerinden sonra hastanın nötropenisinin valproik aside bağlı olduğu saptandı. VaI-poik asit tedavisi sonlandırılan hastanın kan değerleri hızla düzeldi. Valproik aside bağlı nötropeni, bu olguda nötropenik ateşe neden olduğu için yayınlamak istedik.

Anahtar Kelimeler:

Nötropeni, Valproik asit, Ateş, Süt çocuğu, Epilepsi, Antikonvülzanlar

Valproik aside bağlı nötropeni

Valproic acid is an important anticonvulsant agent but it has some serious side effects. Neutropenia is one of them. A one-year old female patient applied to our hospital for control. Neutropenia was determined in her complete blood count. She was given some specific diagnostic tests to explain the cause of neutropenia. At the end of the evaluation,it was thought that neutropenia was due to valproate. The patient's hematological parameters improved after stopping drug apply. This case was found interesting enough to be presented since VPA-induced neutropenia had caused fever.

Keywords:

Neutropenia, Valproic Acid, Fever, Infant, Epilepsy, Anticonvulsants,

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