Ayse KARAOGULLARİNDAN, Osman KÜRŞAT ARIKAN, Sıdıka Deniz YALIM

OBSTRÜKTİF UYKU APNE SENDROMLU HASTALARDA APNE HİPOPNE İNDEKSİ İLE NÖTROFİL LENFOSİT ORANI VE PLATELET LENFOSİT ORANININ İLİŞKİSİ

Amaç: Bu çalışmanın amacı, OUAS’lu hastalarda, cinsiyetlere göre AHİ ile NLO ve PLO arasındaki ilişkinin değerlendirilmesi ve NLO ile PLO’ nun PSG öncesi hastalığın şiddeti ile ilgili bir belirteç olup olamayacağının incelenmesidir. Materyal ve Metot: Çalışmamız, retrospektif ve kesitsel bir çalışma olup, çalışmamızda Mart 2018- Nisan 2018 tarihleri arasında Adana Şehir Eğitim ve Araştırma Hastanesi Kulak Burun Boğaz polikliniğine horlama ve uyku apnesi şikayeti ile başvurup PSG yapılan hasta kayıtları değerlendirildi. PSG yapılan hastalardan AHİ 0- 4,9 olan 1. Grup, AHİ 5-14,9 olan 2. Grup, 15-29,9 olan 3. grup ve AHİ >30 olan hasta 4. Grup olarak alındı. Çalışmaya dahil edilen hastalardan rutin olarak istenen kan sayımı sonuçlarından nötrofil, lenfosit ve platelet sonuçlarına bakıldı. Bulgular: Çalışmaya 138 hasta alındı. Çalışmaya dahil edilen hastaların 106’sı erkek, 32’si kadındı. Genel yaş ortalaması 45,3 (erkeklerde 43,3; kadınlarda 50,4), BMI ortalaması 30,1 (min: 19 – max: 51) bulundu. AHİ ortalaması 23,7 (min: 0, 3-max:103), PLO ortalaması 113,1 (erkeklerde 111,2; kadınlarda 119,5) ve NLO ortalaması 1,93 (erkeklerde 1,99; kadınlarda 1,72) olarak saptandı. Bizim çalışmamızda en yüksek PLO değeri grup 2 de , en yüksek NLO değeri grup 3 te saptandı. En düşük NLO ve PLO değeri diğer çalışmalardaki sonuçlardan farklı olarak grup 4 te saptandı. Fakat gruplar arası incelemede istatistiksel olarak anlamlı bir farklılık saptanmadı. Sonuç: OUAS’da AHİ ile NLO ve PLO ilişkisini daha net anlayabilmek için daha kapsamlı ve çok merkezli çalışmalara ihtiyaç vardır.

Relationship Between Apnea Hypopnea Index, Neutrophil Lymphocyte Ratio And Platelet Lymphocyte Ratio in Patients With Obstructive Sleep Apnea Syndrome

Aim: The aim of this study was to assess the association between apnea-hypopnea index (AHI) with neutrophil lymphocyte ratio (NLO) and platelet lymphocyte ratio (PLO) according to gender in patients with obstructive sleep apnea syndrome (OSAS) and to investigate whether PLO and NLO can be a predictor of disease severity before polysomnography. Material and Method This study was designed as retrospective and cross-sectional, between March 2018 and April 2018, The patients who underwent PSG who were admitted to the Otorhinolaryngology outpatient clinic of Adana City Training and Research Hospital with the complaint of snoring and sleep apnea were evaluated. The study population was divided in to four groups: (i) first group described as; AHI 0-4.9 (ii) second group described as; 5-14.9 (iii) third group described as; AHI 15-29.9 and (iv) fourth group decribed as AHI ≥30 according to polyspmnography (PSG). Neutrophil, lymphocyte and platelet results were evaluated routinely from the blood count results. Results: Of the patients included in the study, 106 were male and 32 were female. The mean age was 45.3 (43,3 for males and 50,4 for females), the mean body mass index (BMI) was 30.1 (min: 19 - max: 51), the mean AHI was 23.7 (min: 0,3 max: 103), the mean PLO was 113,1 (male:111.2 , female: 119.5) and the mean NLO was 1,93 (male:1.99, female:1.72 ) . In our study, the highest PLO value was found in group 2 and the highest NLO value was found in group 3. The lowest NLO and PLO values were found in group 4, unlike the results from other studies. However, no statistically significant difference was found between the groups. Conclusıons: In OSAS, there is a need for more comprehensive prospective and multi-centered study to better understand AHI and NLO, PLO relationship,

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