GEBELİK YAŞINA GÖRE NORMAL VE DÜŞÜK DOĞUM AĞIRLIKLI PREMATÜRE BEBEKLERDE MORTALİTE VE MORBİDİTELERİN KARŞILAŞTIRILMASI

Amaç: Gebelik yaşına göre küçük (SGA) ve normal (AGA) doğum ağırlığı olan çok düşük doğum ağırlıklı prematüre bebeklerde (ÇDDA) morbiditeleri ve mortaliteyi karşılaştırmaktır. Materyal ve Metot: Ünitemizde 2013-2017 yılları arasında izlenen ÇDDA’lı bebeklerin kayıtları retrospektif olarak incelendi. SGA, doğum ağırlığının gebelik haftasına göre 10 persentilin altında olması, AGA doğum ağırlığının 10-90 persentil arasında olması olarak tanımlandı. Toplam 96 SGA’sı olan bebek çalışma grubu ve çalışma grubunun gestasyon haftasına uygun olarak rastgele seçilen 204 AGA olan bebek kontrol grubu olarak belirlendi. Major konjenital anomalisi olan ve verilerinde eksiklik olan bebekler çalışma dışı bırakıldı. Bulgular: SGA ve AGA gurubunda ortalama gestasyon yaşı (28.3±1.1–28.3±1.2, sırasıyla, p=0.94) ve doğum ağırlığı ise (769±144–1132±190 gr, sırasıyla,

COMPARISON OF MORTALITY AND MORBIDITIES IN SMALL AND APPROPRIATE FOR GESTATIONAL AGE PRETERM INFANTS

Aim: To compare morbidity and mortality in very low birth weight premature infants (VLBW) with small (SGA) and appropriate (AGA) for gestational age. Materials and Methods: The records of infants with VLBW who were followed up in our unit between 2013 and 2017 were retrospectively analyzed. SGA was defined as the birth weight being below the 10th percentile compared to the gestational week and the AGA birth weight being between the 10th and 90th percentile. A total of 96 SGA infants were identified as the study group and 204 AGA infants randomly selected and matched with the gestational week of the study group. Infants with major congenital anomalies and lack of data were excluded from the study. Results: The mean gestational age (28.3 ± 1.1–28.3 ± 1.2, p = 0.94) and birth weight (769 ± 144–1132 ± 190 g,

___

  • 1. Griffin IJ, Lee HC, Profit J, Tancedi DJ. The smallest of the small: short-term outcomes of profoundly growth restricted and profoundly low birth weight preterm infants. J Perinatol. 2015;35(7):503–10.
  • 2. Pallotto EK, Kilbride HW. Perinatal outcome and later implications of intrauterine growth restriction. Clin Obstet Gynecol. 2006;49(2):257–69.
  • 3. Comittee on Practice Bulletins-Gynecology,American College of Obstetricians and Gynecologists. Intrauterine growth restriction. Clinical management guidelines for obstetrician-gynecologists. Int J Gynecol Obstet. 2001;72(1): 85–96.
  • 4. Fenton TR. A new growth chart for preterm babies: Babson and Benda's chart updated with recent data and a new format. BMC Pediatr. 2003;3:13.
  • 5. Oygür N, Önal EE, Zenciroğlu A. Turkish Neonatal Society national guideline for the delivery room management. Turk Pediatri Ars. 2018;53(Suppl 1): S3-S17.
  • 6. Köksal N, Aygün C, Uras N. Turkish Neonatal Society guideline on the management of patent ductus arteriosus in preterm infants. Turk Pediatri Ars. 2018;53(Suppl 1):S76-S87.
  • 7. Özkan H, Erdeve Ö, Kanmaz Kutman HG. Turkish Neonatal Society guideline on the management of respiratory distress syndrome and surfactant treatment. Turk Pediatri Ars. 2018;53(Suppl 1):S45- S54.
  • 8. Satar M, Engin Arısoy A, Çelik İH. Turkish Neonatal Society guideline on neonatal infections - diagnosis and treatment. Turk Pediatri Ars. 2018;53(Suppl 1): S88-S100.
  • 9. Kültürsay N, Bilgen H, Türkyılmaz C. Turkish Neonatal Society guideline on enteral feeding of the preterm infant. Turk Pediatri Ars. 2018;53(Suppl 1): S109-S118.
  • 10. Arsan S, Korkmaz A, Oğuz S. Turkish Neonatal Society guideline on prevention and management of bronchopulmonary dysplasia. Turk Pediatri Ars. 2018;53(Suppl 1): S138-S150.
  • 11. Koç E, Yağmur Baş A, Özdek Ş, Ovalı F, Başmak H. Turkish Neonatal and Turkish Ophthalmology Societies consensus guideline on the retinopathy of prematurity. Turk Pediatri Ars. 2018;53(Suppl 1): S151-S160.
  • 12. Papile LA, Burstein J, Burstein R, Koffler H. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. J Pediatr. 1978;92(4):529-34.
  • 13. Bell MJ: Neonatal necrotizing enterocolitis. N Engl J Med. 1978;298:281–2.
  • 14. MalhotraA SA, Miller SL, Jenkin G, Polglase GR. The efficacy of surfactant replacement therapy in the growth-restricted preterm infant: what is the evidence? Front Pediatr. 2014;2:118.
  • 15. Qiu X, Lodha A, Shah PS, Sankaran K, Seshia MMK, Yee W, et al. Neonatal outcomes of small for gestational age preterm infants in Canada. Am J Perinatol. 2012(2);29:87–94.
  • 16. Rozance PJ, Seedorf GJ, Brown A, Roe G, O’Meara MC, Gien J, et al. Intrauterine growth restriction decreases pulmonary alveolar and vessel growth and causes pulmonary artery endothelial cell dysfunction in vitro in fetal sheep. Am J Physiol Lung Cell Mol Physiol. 2011;301:L860–L71.
  • 17. Thébaud B, Abman SH. Bronchopulmonary dysplasia where have all the vessels gone? Roles of angiogenic growth factors in chronic lung disease. Am J Respir Crit Care Med. 2007;175(10):978–85.
  • 18. Nobile S, Marchionni P, Carnielli VP. Neonatal outcome of small for gestational age preterm infants. Eur J Pediatr. 2017;176(8):1083-8.
  • 19. Sharma P, McKay K, Rosenkrantz TS, Hussain N. Comparisons of mortality and pre-discharge respiratory outcomes in small-for-gestational-age and appropriate-for-gestational-age premature infants. BMC Pediatr. 2004;4:9.
  • 20. Soudée S, Vuillemin L, Alberti C. Fetal growth restriction is worse than extreme prematurity for the developing lung. Neonatology. 2014(4);106:304–10.
  • 21. Koenig JM, Christensen RD. Incidence, neutrophil kinetics, and natural history of neonatal neutropenia associated with maternal hypertension. N Engl J Med. 1989;321:557–62.
  • 22. Simchen MJ, Beiner ME, Strauss-Liviathan N, Dulitzky M, Kuint J, Mashiach S, et al. Neonatal outcome in growth-restricted versus appropriately grown preterm infants. Am J Perinatol. 2000;17(4):187-92.
  • 23. Ree IM, Smits-Wintjens VE, Rijntjes-Jacobs EG, Pelsma IC, Steggerda SJ, Walther FJ, et al. Necrotizing enterocolitis in small-for-gestational-age neonates: a matched case-control study. Neonatology. 2014;105(1):74-8.
  • 24. Lin PW, Stoll BJ. Necrotising enterocolitis. Lancet. 2006;368:1271–83.
  • 25. Garite TJ, Clark R, Thorp JA. Intrauterine growth restriction increases morbidity and mortality among premature neonates. Am J Obstet Gynecol. 2004; 191(2):481–7.
  • 26. Baer RJ, Rogers EE, Partridge JC, Anderson JG, Morris M, Kuppermann M, et al. Population-based risks of mortality and preterm morbidity by gestational age and birth weight. J Perinatol. 2016;36(11):1008-13.
Namık Kemal Tıp Dergisi-Cover
  • ISSN: 2587-0262
  • Başlangıç: 2013
  • Yayıncı: Erkan Mor
Sayıdaki Diğer Makaleler

KÜÇÜK HÜCRELİ OLMAYAN AKCİĞER KANSERİ HÜCRELERİNDE LET-7B-5P’NİN APOPTOTİK GENLER İLE İLİŞKİSİNİN ARAŞTIRILMASI

ESRA BOZGEYİK

GAZİOSMANPAŞA TAKSİM EĞİTİM ARAŞTIRMA HASTANESİ AİLE HEKİMLİĞİ POLİKLİNİĞİNE BAŞVURAN ERİŞKİN BİREYLERDE RİSK DEĞERLENDİRME SKORLAMA SİSTEMİ KULLANILARAK TİP 2 DİYABET RİSKİNİN TARANMASI

Muhammet Ali İĞCİ, OKCAN BASAT

TİROİD NODÜLLERİNDE MALİGN VE BENİGN AYRIMINDA DİFÜZYON AĞIRLIKLI MANYETİK REZONANS İNCELEMENİN YERİ

ÖMER ÖZÇAĞLAYAN, TUĞBA İLKEM KURTOĞLU ÖZÇAĞLAYAN, AHMET MESRUR HALEFOĞLU

ÇOCUK VE ERGEN PSİKİYATRİSİ POLİKLİNİĞİNE BAŞVURAN OLGULARDA SOSYODEMOGRAFİK ÖZELLİKLER, SEMPTOM VE TANI DAĞILIMI

MERİÇ MERİÇLİ, TUĞÇE YILDIZ, SALİHA BAYKAL

İNEK SÜTÜ ALERJİSİNE GÜNCEL YAKLAŞIM

NURŞEN CİĞERCİ GÜNAYDIN

PAMUK İPLİĞİNE BAĞLI HAYATTA BİR UMUT OLMAK: TEKİRDAĞ NAMIK KEMAL ÜNİVERSİTESİ BİRİNCİ SINIF ÖĞRENCİLERİ İÇİN İLK YARDIM EĞİTİMİ PROJESİ

Tülin YILDIZ, A. Handan DÖKMECİ

THE ROLE OF MAGNETIC RESONANCE IMAGING IN DIAGNOSIS OF ARRHYTHMOGENIC RIGHT VENTRICLE DYSPLASIA

HADİ SASANİ, Memduh DURSUN, AHMET KAYA BİLGE

BİR TARIM COĞRAFYASI OLAN TRAKYA’ DA DUPUYTREN HASTALIĞI’ NIN EPİDEMİYOLOJİK PROFİLİNİN İNCELENMESİ

Özgür AGDOĞAN, Uğur TOSUN

KRONİK KARACİĞER HASTALIĞINDA SİSTERNA ŞİLİ ÇAPININ MANYETİK REZONANS GÖRÜNTÜLEME İLE DEĞERLENDİRİLMESİ

Sadık SERVER

GEBELİK YAŞINA GÖRE NORMAL VE DÜŞÜK DOĞUM AĞIRLIKLI PREMATÜRE BEBEKLERDE MORTALİTE VE MORBİDİTELERİN KARŞILAŞTIRILMASI

Gülsüm KADIOĞLU ŞİMŞEK, Mehmet BÜYÜKTİRYAKİ, H. Gözde KANMAZ KUTMAN, Tuğba ALARCON MARTİNEZ, Şerife Suna OĞUZ, CÜNEYT TAYMAN, Fuat Emre CANPOLAT