Şengül Talar ARSLAN, Bünyamin BÖREKÇİ, Emsal Pınar TOPDAĞI

ENDOMETRİOZİSE BAĞLI AĞRI TEDAVİSİNDE LEVONORGESTREL SALGILAYAN RAHİM İÇİ ARAÇ SİSTEMİ (LNG-RİA) VE NAPROKSEN SODYUM ETKİNLİĞİ KARŞILAŞTIRILMASI

Amaç: Endometriozis, birçok semptomu olmasına rağmen en sık beraber olduğu semptom ağrıdır. Ağrınınsebebi net olarak bilinmemektedir. Çalışmamızda endometriozise bağlı ağrısı olan hastalarda güncel tedavi yaklaşımlarından biri olan LNG-RİA (levonorgestrel salgılayan rahim içi araç sistemi) ve bir nonsteroid antiinflamatuar ajan olan naproksen sodyumun etkinliğini karşılaştırılmasını amaçladık. Gereç ve Yöntem: Etik kurul onayı alındıktan sonra kliniğimizde opere edilip patolojisi endometriozis gelen 60 hasta çalışmaya dahil edildi. 20 hasta kontrol grubu, 20 hasta LNG-RİA grubu, 20 hasta naproksen sodyum grubu olarak alındı. Hastalara McGill ağrı soru formu ve aylık ağrı formu verildi. Visüel analog skala kullanılarak doldurulması istendi. Hastalar aylık kontrollere çağrıldı. Bulgular: Yapılan istatistiksel testler sonucunda LNG-RİA uygulanan hasta grubunda VAS ağrı ortalamasında 1. aydan 6. aya anlamlı azalma bulundu. Naproksen sodyum grubunda ise pelvik ağrıda ve dismenorede azalma olduğu; ancak ağrının şiddetindeki azalmanın aylar arasında farklılık göstermediği görüldü. Sonuç: Endometriozise bağlı ağrı tedavisinde birçok medikal ajan kullanılmaktadır. LNG-RİA endometriozise bağlı ağrı tedavisinde, yan etki profili ve sürekli kullanım gerektirmemesi yönüyle daha etkin bir tedavidir.

Anahtar Kelimeler:

Endometriozis, levonorgestrel salgılayan rahim içi araç (LNG-RİA), naproksen sodyum, ağrı tedavisi

In Endometriosis Treatment of Pain Due Levonorgestrel Releasing Intrauterine Vehicle System (LNG-IUD) to Event and Comparison Naproxen Sodium

Aim: Although there are many symptoms of endometriosis, the most frequent symptom is pain. The cause of pain is unknown. In this study, it is aimed to compare efficiency of LNG-IUD (levonorgestrel releasing intrauterine vehicle system) and the non-steroidal anti-inflammatory agent, naproxen sodium which are two current approaches in the management of endometriosis-related pain.Material and Methods: After approval of the Ethics Committee, 60 patients, who were operated with the pathology of endometriosis, were included in the study.It is divided into three groups and each group cotained 20 patients.They are named as the control group, the LNG-IUD group, and the naproxen sodium group. McGill pain questionnaire and pain questionnaire form were given to patients monthly. Patients were asked to fill out the forms using a visual analogue scale. Patients were followed-up monthly.Results: As a result of the statistical tests applied, there was a significant decrease in the mean VAS score in the LNG- IUD patient group from 1st to the 6th months of treatment. Reduction of pelvic pain and dysmenorrhea was detected in the naproxen sodium group, but it did not differ the decrease in pain severity between months Conclusion: A number of medical drugs are used in the management of endometriosis-related pain. It can be concluded that LNG-IUD was a more effective due to modality in the management of endometriosis-related pain, and has both low side effct and no need to be used continously.

Keywords:

Endometriosis, levonorgestrel releasing intrauterine device (LNG IUD), naproxen sodium, pain management,

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