İleri Evre Orofarenks Kanserli Bir Hastada Nekroze Enfekte Tümöral Kitlede Cedecea Lapagei Süperenfeksiyonu: Olgu Sunumu (Cedecea lapagei süperenfeksiyonu)

Sıklıkla balgamdan izole edilen ve Enterobacteriaceae ailesinin bir üyesi olan Cedecea cinsi bakteriler ciltte normal florada bulunmazlar ancak gastrointestinal sistemde kolonize olabilirler. Buna karşın klinik önemleri henüz net değildir. Sıklıkla immunsupresyonu olan hastalarda gelişen Cedecea enfeksiyonlarının nadir olduğu belirtilmiştir. Literatürde bakteriyemi, abse, ülser, idrar yolu, pnömoni, göz ve yara enfeksiyonları nadir olgular olarak bildirilmiştir. Bu yazıda sisplatin, 5-fluorourasil, setuksimab anti-kanser ilaçlarından oluşan kombinasyon rejimi ile tedavi edilen ileri evre orofarenks skuamöz hücreli karsinom tanılı erkek hastada gelişen C. lapagei yara enfeksiyonu sunulmuştur.

Anahtar Kelimeler:

Cedecea Lapagei, Cedecea Türleri, Yara Enfeksiyonu

Cedecea Lapagei Superinfection in a Tumoral Mass of Locally Advanced Oropharyngeal Carcinoma: a Case Report (Cedecea lapagei superinfection)

Cedecea type of bacteria that is isolated from sputum and a member of Enterobacteriaceae is not found in skin flora. However, it may be colonised in the gastrointestinal system. On the other hand, the clinical importance of it has not been well documented. It has been rarely reported in immunosuppressive individuals. In literature, it is reported that bacteraemia, abscess, ulcer, urinary tract infection, pneumonia, eye and wound infections associated with Cedecea lapagei are the rare cases. Here, were present a Cedecea lapagei related wound infection in a locally advanced oropharyngeal squamous cell carcinoma treated with cisplatin, 5-fluorouracil and cetuximab.

Keywords:

Cedecea Lapagei, Cedecea Species, Wound Infection,

PDF

___

1. Abbott SL. Klebsiella, Enterobacter, Citrobacter, Serratia, Plesiomonas, and other Enterobacteriaceae, pp: 684- 700. In: Murray PR, Baron EJ, Jorgensen JH, Pfaller MA, Yolken RH (eds), Manual of Clinical Microbiology. 2003, 8th ed. ASM Press, Washington, D.C.
2. Mawardi H, Pavlakis M, Mandelbrot D, Woo SB. Sirolimus oral ulcer with Cedecea davisae superinfection. Transpl Infect Dis. 2010;12:446-50.
3. Perkins R, Beckett TA, Bump CM. Cedecea davisae bacteremia. J Clin Microbiol. 1986;24(4):675-6.
4. Farmer JJ, Sheth NK, Hudzinski JA, Rose HD, Asbury MF. Bacteremia due to Cedecea neteri sp. nov. J Clin Microbiol. 1982;16(4):775-8.
5. Dalamaga M, Pantelaki M, Karmaniolas K, Matekavits A, Daskalopoulou K. Leg ulcer and bacteremia due to Cedecea davisae. Eur J Dermatol. 2008;18(2):204-5.
6. Farmer JJ 3 rd, Sheth NK, Hudzinsky JA, Rose HD, Asbury MF. Bacteremia due to Cedecea neteri sp. nov. J Clin Microbiol. 1982;16:775-8.
7. Aguilera A, Pascual J, Loza E, , et al. Bacteremia with Cedecea neteri in a patient with systemic lupus erythematosus. Postgrad Med J. 1995;71:179-80.
8. Bae BH, Sureka SB. Cedecea davisae isolated from scrotal abscess. J Urol. 1983;130:148-9.
9. Pande BN, Krysinska-Traczyk E, Prazmo Z, Skorska C, Sitkowska J, Dutkiewicz J. Occupational biohazards in agricultural dusts from India. Ann Agric Environ Med. 2000;7:133-9.
10. Yetkin G, Ay S, KayabasU, Gedik E, GucluerN, Caliskan A. A pneumonia case caused by Cedecea lapagei. Mikrobiyol Bul. 2008;42:681-4.
11. Ağca H, Bozkurt M. A pneumonia case caused by Cedecea Lapagei. J Clin Anal Med. 2014:5:147-8.
12. Çekin Y, Kızılateş F, Dolu S, Öztoprak N, Çekin AH. The first urinary tract infection caused by Cedecea lapagei: a case report and review of the literature. Gaziantep Med J. 2014;20:193-5.
13. Hassu Ö, Çelik İ. An Uncommon Cause of Bacteremia: Cedacia lapagei. Flora. 2018;23(2):88-91.
14. Davis O, Wall BM. “Broom straw peritonitis” secondary to Cedacia lapagei in a liver transplant recipient. Perit Dial Int. 2006;26(4):512-3.
15. Dalamaga M, Karmaniolas K, Arsenis G, et al. Cedecea lapagei bacteremia following cement-related chemical burn injury. Burns. 2008;34(8):1205-7.
16. Lopez LA, Ibarra BS, de La Gorza JA, Nunez AI, Lopez MB. First reported case of pneumonia caused by Cedecea lapagei in America. Braz J Infect Dis. 2013;17(5):626-8.
17. Salazar G, Almeida A, Gomez M. Cedecea lapagei traumatic wound infection: case report and literature review. Rev Chilena Infectol. 2013;30(1):86-9.
18. Biswal I, Hussain NA, Grover RK. Cedecea lapagei in a patient with malignancy: Report of a rare case. J Can Res Ther. 2015;11:646.
19. Cardenas JL. Acute osteomyelitis by Cedecea lapagei. Acta Med Colomb. 2015;40(3):246-8.
20. Hong SK, Lee JS, Kim EC. First Korean case of Cedecea lapagei pneumonia in a patient with chronic obstructive pulmonary disease. Korean J Lab Med. 2015;35:266-8.
21. Aguilar GA, Basurta AL, Luna AG, Esquivel VHN, Barajas JAS. Cedecea lapagei bacteremia: a case report in Mexico. Acta Medica Grupo Angeles. 2016;14(3):176-8.
22. Kurry CMH, Yabrudi AA, de Souza TB, et al. First reported case of ventilator-associated pneumonia and sepsis caused by Cedecea lapagei in a Brazilian Neonatal Intensive Care Unit. J Pediat Inf Dis. 2017;6(2):209-10.
23. Herrera VRC, de Silva MFR, Alcanaz HO, Espiritu GC, Pena KC, Melnikov V. Death rrelated to Cedecea lapagei in a soft tissue bullae infection. A case report. J Med Case Rep 2018;12:328.