Deneysel Kolon Anastomoz Kaçağı Modeli: Sütür Sayısı Azaltılarak Yapılan Anastomoz Deneysel Anastomoz Kaçağı Modeli

Bu çalışmada deneysel kolon anastomoz kaçağı modeli olarak ratlarda sütür sayısı azaltılarak yapılan anastomoz yeni bir yöntem olarak uygulandı. Çalışma yöntemi olarak kontrol grubuna 8 sütür ile çalışma grubuna 4 sütür ile kolo-kolik uç uca anastomoz uygulandı. Postoperatif 5.gün her iki grupta da anastomoz yapılan kolon segmentleri rezeke edilerek patlama basınçları ölçüldü ve anastomoz kaçakları gözlendi. Çalışma sonucunda sütür sayısı azaltılarak yapılan anastomoz kaçağı modelinin deneysel çalışmalarda kullanılabileceği sonucuna varıldı.

Anahtar Kelimeler:

Anastomoz, Deneysel Çalışma, Patlama Basıncı

Experimental Colon Anastomosis Leakage Model: Anastomosis by Reducing The Number of Sutures Experimental Anastomosis Leakage Model

In this study, anastomosis was applied as a new method by reducing the number of sutures in rats as an experimental model of colon anastomosis leakage. Colo-colic, end-to-end anastomosis was applied with 8 sutures to the control group and 4 sutures to the study group. Postoperative 5.day after anastomotic segment resection, burst pressures were measured and anastomosis leaks were observed. The study concluded that the model of anastomosis leakage made by reducing the number of sutures could be used in experimental studies.

Keywords:

Anastomosis, Burst Pressure, Experimental Study,

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1. Komen N, van der Wal HC, Ditzel M, et al. Colorectal Anastomotic Leakage: A New Experimental Model. J Surg Res. 2009;155(1):7-12.
2. Wenger FA , Szucsik E , Hoinoiu BF, et al. New Anastomotic Leakage Model in Circular Double Stapled Colorectal Anastomosis After Low Anterior Rectum Resection in Pigs. J Invest Surg. 2013;26(6):364-72.
3. Hoeppner J, Crnogorac V, Hopt UT, et al. The Pig as an Experimental Model for Colonic Healing Study of Leakage and Ischemia in Colonic Anastomosis. J Invest Surg. 2009;22(4):281-5.
4. Nordentoft T, Sørensen M. Leakage of colon anastomoses: development of an experimental model in pigs. Eur Surg Res. 2007;39(1):14-6.
5. Barneveld KWY, Vakalopoulos KA, Bosmans JW, et al. Colorectal Anastomotic Leakage: A new, Validated Rat Model. Int J Surg Res. 2016;3(6):61-7.
6. Wang Y, Cai X, Jin R, et al. Experimental Study of Primary Repair of Colonic Leakage with a Degradable Stent in a Porcine Model. J Gastrointest Surg. 2011;15(11):1995–2000.
7. Tsereteli Z, Sporn E, Geiger TM, et al. Placement of a covered polyester stent prevents complications from a colorectal anastomotic leak and supports healing: randomized controlled trial in a large animal model. Surgery. 2008;144(5):786–92.
8. Nordentoft T, Sørensen M. Leakage of Colon Anastomoses: Development of an Experimental Model in Pigs. Eur Surg Res. 2007;39(1):14-6.
9. van der Ham AC, Kort WJ, Weijma IM,et al. Transient protection of incomplete colonic anastomoses with fibrin sealant: an experimental study in the rat. J Surg Res. 1993;55(3): 256–60.
10. Hau J, Van Hoosier Jr. GL. Handbook of Laboratory Animal Science, 2nd edn. Washington: CRC Press, 2003.
11. Pommergaard HC. Experimental Evaluation of Clinical Colon Anastomotic Leakage. Dan Med J. 2014;61(3):B4821.