F-18 FDG PET/CT Scan Maybe More Helpfull Instead of Ga-68 PSMA Scan in the Case of Ductal Variant Prostate Cancer

F-18 FDG PET/CT Scan Maybe More Helpfull Instead of Ga-68 PSMA Scan in the Case of Ductal Variant Prostate Cancer

Imaging plays an important role in the evaluation of prostate cancer patients. In recent years, much attention has been focused on 68Ga-PSMA PET-CT in prostate cancer patients and has been widely used for staging, especially biochemical relapse-restaging and therapy response for these patients. We hereby, report the rare case of a ductal variant prostate cancer patient and present both Ga-68 PSMA and FDG PET-CT imaging findings.

___

  • 1. Perera M, Papa N, Christidis D, et al. Sensitivity, specificity, and predictors of positive 68Ga–prostate-specific membrane antigen positron emission tomography in advanced prostate cancer: a systematic review and meta-analysis. Eur Urol 2016; 70: 926-37
  • 2. Larson SM, Morris M, Gunther I, Beattie B, Humm JL, Akhurst TA, Finn RD, Erdi Y, Pentlow K, Dyke J, Squire O, Bornmann W, McCarthy T, Welch M, Scher H. Tumor localization of 16beta-18F-fluoro-5alpha-dihydrotestosterone versus 18F-FDG in patients with progressive, metastatic prostate cancer. J Nucl Med. 2004 Mar;45(3):366-73
  • 3. Maurer T, Gschwend JE, Rauscher I, et al. Diagnostic efficacy of (68)gallium-PSMA positron emission tomography compared to conventional imaging for lymph node staging of 130 consecutive patients with intermediate to high risk prostate cancer. J Urol 2016; 195: 1436-43
  • 4. Dewes S, Schiller K, Sauter K, et al. Integration of (68) Ga-PSMA-PET imaging in planning of primary definitive radiotherapy in prostate cancer: a retrospective study. Radiat Oncol 2016; 11: 73.
  • 5. Shakespeare TP. Effect of prostate-specific membrane antigen positron emission tomography on the decision-making of radiation oncologists. Radiat Oncol 2015;10: 233
  • 6. Roach PJ, Francis R, Emmett L, et al. The impact of 68Ga-PSMA PET/CT on management intent in prostate cancer: results of an Australian prospective multicenter study. J Nucl Med 2018; 59: 82-8
  • 7. Fendler WP, Schmidt DF, Wenter V, et al. 68Ga PSMA PET/CT detects the location and extent of primary prostate cancer. J Nucl Med 2016; 57: 1720-5
  • 8. Kuten J, Mabjeesh N.J., Lerman H, et. al. 68Ga-PSMA PET/CT Staging of Newly Diagnosed Intermediate- and High-Risk Prostate Cancer. IMAJ.Vol 21.February 2019
  • 9. McEwan L.M., Wong D., Yaxley J. Flourodeoxyglucose ppositron emission tomography scan may be helpful in the case of ductal variant prostate cancer when prostate specific membrane antigen ligand positron emission tomography scan is negative. Journal of Medical Imaging and Radiation Oncology 61 (2017) 503-505