Erek ULUTAŞ, Semih BULUT, Didem DELİORMAN ORHAN

Piyasada Kişniş Olarak Satılan Örneklerin Avrupa Farmakopesi Kriterleri Yönünden İncelenmesi

Amaç: Kişniş (Coriandrum sativum L.) meyveleri gıda olarak ve tıbbi amaçlarla kullanılmaktadır. Piyasada satılan ve tıbbi amaçlarla kullanılan kişniş meyvelerinin kalite kriterleri hakkında bir bilgi mevcut değildir. Bu sebeple, özellikle karminatif, antispazmotik ve iştah arttırıcı özellikleri sebebiyle sıklıkla kullanılan ve 12 farklı aktardan satın alınan kişniş örneklerinin kalite kontrolleri Avrupa Farmakopesi 8.0 standartlarına göre araştırılmıştır.Yöntem: Kişniş numunelerinin standartlara uygunluğunu belirlemek için Avrupa Farmakopesi 8.0’da yer alan “Coriandri fructus’’ monografı kullanılmıştır. Örnekler, monografta belirlenen tüm analizler (morfolojik, mikroskobik, ince tabaka kromatografisi, yabancı madde, total kül, kurutmada kayıp ve uçucu yağ miktar tayini analizleri) için değerlendirilmiştir.Bulgular: Bütün numunelerin morfolojik, mikroskobik, kurutmada kayıp, ince tabaka kromatografisi ve total kül miktarı analiz sonuçlarının Farmakopeye uygunluk gösterdiği, bir kısım numunenin yabancı madde ve uçucu yağ miktar tayini sonuçlarının Farmakope standartlarına uygunluk göstermediği tespit edilmiştir. Sonuç: Analiz sonuçlarına göre incelenen 12 numunenin Avrupa Farmakopesi 8.0 standartlarına uygun olmadığı tespit edilmiştir. Bu çalışma ile bu tip bitkisel ürünlerin tıbbi amaçlarla ve fitoterapide kullanılmasının halk sağlığı açısından uygun olmadığı ve bu ürünlerin kalite kontrol analizleri yapıldıktan sonra eczanelerde satılmasının önemi bir kez daha ortaya çıkmıştır.

Anahtar Kelimeler:

Apiaceae, Avrupa Farmakopesi, Coriandrum sativum, Fitoterapi, Kişniş

An Investigation of the Samples Sold as Coriander in the Market in Terms of the European Pharmacopoeia Criteria

Aim: Coriander (Coriandrum sativum L.) fruits are used as food and for medicinal purposes. There is no information about the quality criteria of coriander fruits sold in the market and used for medicinal purposes. For this reason, quality controls of coriander samples, which are frequently used due to its carminative, antispasmotic and appetite enhancing properties and purchased from 12 different herbalists, have been investigated according to the European Pharmacopoeia 8.0 standards.Method: "Coriandri fructus" monograph in European Pharmacopoeia 8.0 was used to determine the quality of the Coriander samples. Samples were evaluated for all analyzes (morphological, microscopic, thin layer chromatography, foreign matter, total ash, loss in drying and essential oil quantification analysis) identified in the monograph.Results: Morphological, microscopic, loss in drying, thin layer chromatography and total ash analysis results of all samples were found to be in accordance with Pharmacopoeia, and foreign matter and essential oil quantification results of some samples did not comply with Pharmacopoeia standards.Conclusion: According to the results of the analysis, it was determined that the 12 samples examined were not compliant with the European Pharmacopoeia 8.0 standards. With this study, it was once again revealed that the use of these types of herbal products for medicinal purposes and phytotherapy is not suitable for public health and the importance of selling these products in pharmacies after quality control analysis has been made.

Keywords:

Apiaceae, European Pharmacomacopoeia, Coriandrum sativum, Phytotherapy, Coriander,

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