Feryal KARAHAN, Cem Hasan RAZİ, Ayşe Derya BULUŞ, Nesibe ANDIRA

Okul öncesi çocuklarda serum 25-hidroksi D vitamin düzeyleri ile tekrarlayan hışıltı arasındaki ilişki

Amaç: Çevresel faktörlerden biri olan 25-hidroksi D vitamininin okul öncesi çocuklarda tekrarlayan hışıltı ataklarına etkisini araştırmak. Yöntem: Çalışmaya Keçiören Eğitim ve Araştırma Hastanesi Çocuk Alerji Polikliniği’nde tekrarlayan vizing atağı nedeni ile takipli 77 hasta, kontrol grubuna benzer yaş grubunda olan çocuk sağlığı polikliniğine başvuran 74 sağlıklı çocuk alındı. Hasta ve kontrol grubunun dosyaları incelenerek çocukların ağırlık, boy, doğum şekli, anne yaşı, D vitamini kullanma süresi, beslenme öyküsü ve ayrıca hasta grubundakilerin ilk vizing atak zamanı, vizing atak sayısı ve vizing nedeniyle hastaneye yatış sayısı belirlendi. Her iki grupta serum kalsiyum, fosfor ve 25-Hidroksi D vitamini düzeyleri çalışıldı. Bulgular: Hasta grubunun 54’ü (%70.1) erkek, 23’ü (%29.9) kız, ortalama yaşları 29.5±1.9 ay olup kontrol grubunun 44’ü (%59.5) erkek, 30’u (%40.5) kız ve ortalama yaşları 31.7±18.1 aydı. Hasta grubunda serum D vitamini düzeyi ile ilk vizing atak zamanı, vizing atak sayısı ve hastaneye yatış sayıları arasında bir ilişki bulunmadı. Hasta grupta astım prediktif indeksi pozitif olanların vizing atak sayısının negatif olan gruptan anlamlı olarak daha fazla olduğu ancak serum 25 hidroksi vitamin D vitamini düzeyi ile arasında ilişki olmadığı saptandı. Sonuç: Çalışmamızda serum D vitamini düzeyi ile ilk vizing atak zamanı, vizing atak sayısı ve hastaneye yatış sayısı arasında ilişki saptanmamıştır.

Anahtar Kelimeler:

Okul Öncesi Çocuklar, Tekrarlayan Vizing, Vitamin D

The relation between serum 25-hydroxy vitamin D levels and recurrent wheezing in preschool children

Aim: To investigate the effect of 25-hidroxy D vitamin, one of the environmental factors, on recurrent wheezing episodes in pre-school children. Methods: This research was conducted on77 patients who had recurrent wheezing attacks and were followed by the pediatric allergy department of Keçiören Training and Research Hospital, and other 74 healthy children attending the pediatric clinic with the same age range as the control group. Medical charts of the patients and control group were reviewed to determine the weight, height, delivery method, their mother’s age, duration of vitamin D usage, nutrition history and the time of the first wheezing attacks of the patient group, number of wheezing attacks and the number of hospitalization due to the recurrent wheezing. Serum calcium, phosphorus, and 25-hidroxy vitamin D and levels were evaluated in both groups. Results: Fifty-four (70%) of the patient group were male and 23 (29.9%) of them were female. The mean age was 29.5±17.9 months. Forty-four (59.5%) of the control group were male and 30 (40.5%) of them were female. The mean age was 31.7±18.1 months. There was no relation between serum vitamin D levels, the date of first wheezing attack, total number of wheezing attacks and number of hospitalizations in the patient group. It was found that the number of wheezing attacks of the patients with positive predictive index for asthma was significantly higher than those with negative asthma predictive index but there was no relation with serum 25-hydroxy vitamin D levels. Conclusions: In this research, no relation was found between serum vitamin D levels and the date of first wheezing attack, total amount of wheezing attacks and the number of hospitalizations due to these attacks.

Keywords:

Preschool Child, Recurrent Wheezing, Vitamin D,

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