Bisfenol A (BFA) ve insan üreme sağlığı

Bugün yaşantımızın her anında yer alan plastikler neredeyse tüm ürünlerin içerisinde bulunmaktadır. Plastik üretiminde yaygın bir şekilde kullanılan Bisfenol A (BFA), östrojeni taklit ederek endokrin bozucu gibi davranıp insan üreme sağlığı üzerinde olumsuz etkilere yol açmaktadır. Bu çalışma, BFA’nın üreme sağlığına olan potansiyel etkisini Pubmed veri tabanı kullanılarak bugüne kadar yayınlanan insan temelli çalışmaları inceleyip değerlendirmek amacıyla yapılmıştır. İncelenen literatür sonucunda BFA maruziyetinin ovaryan cevapta, in vitro fertilizasyon (IVF) ve fertilizasyon başarısında azalma, embriyo kalitesi ve sperm kalitesinde düşme, cinsiyet hormon konsantrasyonlarında değişme, erkek cinsel işlev bozukluğu, polikistik over sendromu (PCOS) ile ilişkili olabileceğini göstermektedir. Çalışmaların sonuçları değerlendirildiğinde, BFA maruziyetinin azaltılması (hazır ambalajlı ürünler, plastik kaplar vb. kullanımının azaltılması gibi) hastalıkların önlenmesinde koruyucu bir faktör olabilir. İnsan üreme sağlığı üzerindeki etki mekanizmalarını daha iyi anlamak ve erken aşamalardaki potansiyel üreme toksisitesini tespit etmek için ileri çalışmalara ihtiyaç vardır.

Anahtar Kelimeler:

Endokrin bozucu, Bisfenol A, üreme sağlığı, infertilite

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