The role of triglyceride/glucose index in predicting coronary artery disease severity

Triglyceride-glucose index is a novel marker for metabolic disorders and insulin resistance and is known to be in close association with the presence, prognosis, and severity of coronary artery disease. However, few reports were evaluated the predictability of the Triglyceride-glucose index for the severity of coronary artery disease and the need for coronary intervention in patients undergoing coronary angiography. We aimed to evaluate this predictability in our study. This study was a retrospective observational cohort study. 310 patients diagnosed with coronary artery disease that underwent coronary angiography between April 2019 and March 2020 were randomly selected from the hospital database and evaluated. Index was calculated as Ln (fasting triglyceride (mg/dl) × fasting glucose (mg/dl) / 2). Patients were divided into two groups according to final treatment as Medical or Intervention. While glucose values differed significantly between the groups that underwent medical treatment and interventional treatment, triglyceride measurements were found quite close to each other. However, the value of the Triglyceride-Glucose index differed significantly between the groups (p=0.001). The index was found as 9.15±0.69 in the patients who underwent interventional treatment, and it was found to be lower as 8.91±0.54 in the medical treatment group. While total cholesterol, LDL, and HDL differed significantly between the groups. Creatinine, glomerular filtration rate; and ejection fraction values differed significantly between the groups. Triglyceride-Glucose index that can simply be calculated from routine blood parameters, could be a predictive parameter for complex coronary lesions that could need advanced interventions; yet further investigations are needed.

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