Cardiac heterogeneity in patients with chronic urticaria; A perusal of P wave and QT dispersions

Cardiac heterogeneity in patients with chronic urticaria; A perusal of P wave and QT dispersions

Data on how the heart is affected in Chronic Urticaria (CU), a common annoying chronic dermatological disease, is quite limited. The electrocardiographic parameters; P wave dispersion (PWD) and QT dispersion (QTD) have been consistently reported to be predictive for cardiac arrhythmias and morbidity. We aimed to detect asymptomatic cardiovascular involvement in terms of predisposition to arrhythmias in chronic urticaria. This cross-sectional study included 128 individuals: 64 with CU and 64 healthy controls. 12-lead surface electrocardiogram and Doppler echocardiography were performed on patients and controls. All of the cardiologic parameters such as P wave, PWD, QTD and corrected QTD (QTDc) parameters were obtained from ECG measurements. Maximum P wave duration and PWD were found to be higher in CU patients than controls (P= 0.035 and P

___

  • 1. Radonjic-Hoesli S, Hofmeier KS, Micaletto S, et al. Urticaria and Angioedema: an Update on Classification and Pathogenesis. Clin Rev Allergy Immunol. 2018;54:88-101.
  • 2. Jafilan L, James C. Urticaria and Allergy-Mediated Conditions. Prim Care. 2015;42:473-83.
  • 3. Kocaturk E, Grattan C. Is chronic urticaria more than skin deep? Clin Transl Allergy. 2019;9:48.
  • 4. Chang HW, Cheng HM, Yen HR, et al. Association between chronic idiopathic urticaria and hypertension: A population-based retrospective cohort study. Ann Allergy Asthma Immunol. 2016;116:554-8.
  • 5. Erxun K, Wei L, Shuying Q. Kounis Syndrome Caused by Chronic Autoimmune Urticaria: A Case Report. J Emerg Med. 2016;50:37-40.
  • 6. Kounis NG, Koniari I, Tzanis G, et al. Anaphylaxis-induced atrial fibrillation and anesthesia: Pathophysiologic and therapeutic considerations. Ann Card Anaesth. 2020;23:1-6.
  • 7. Okutucu S, Aytemir K, Oto A. P-wave dispersion: What we know till now? JRSM Cardiovasc Dis. 2016;5:2048004016639443.
  • 8. Baumert M, Porta A, Vos MA, et al. QT interval variability in body surface ECG: measurement, physiological basis, and clinical value: position statement and consensus guidance endorsed by the European Heart Rhythm Association jointly with the ESC Working Group on Cardiac Cellular Electrophysiology. Europace. 2016;18:925-44.
  • 9. Atiga WL, Calkins H, Lawrence JH, et al. Beat-to-beat repolarization lability identifies patients at risk for sudden cardiac death. J Cardiovasc Electrophysiol. 1998;9:899-908.
  • 10. Erre GL, Piras A, Piga M, et al. QT and QT dispersion intervals in longstanding and moderately active rheumatoid arthritis: results from a multicentre cross-sectional study. Clin Exp Rheumatol. 2020;38:516-22.
  • 11. Zhan X, Li C, Wu Q. Cardiac urticaria caused by eucleid allergen. Int J Clin Exp Med. 2015;8:21659-63.
  • 12. Zuberbier T, Aberer W, Asero R, et al. The EAACI/GA²LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria. Allergy. 2018;73:1393-414.
  • 13. Galderisi M, Cosyns B, Edvardsen T, et al. Standardization of adult transthoracic echocardiography reporting in agreement with recent chamber quantification, diastolic function, and heart valve disease recommendations: an expert consensus document of the European Association of Cardiovascular Imaging. Eur Heart J Cardiovasc Imaging. 2017;18:1301-10.
  • 14. Akin C. Mast cell activation disorders. J Allergy Clin Immunol Pract. 2014;2:252-7.e1;quiz 258.
  • 15. Janicki JS, Brower GL, Levick SP. The emerging prominence of the cardiac mast cell as a potent mediator of adverse myocardial remodeling. Methods Mol Biol. 2015;1220:121-39.
  • 16. Wolff AA, Levi R. Histamine and cardiac arrhythmias. Circ Res. 1986;58:1- 16.
  • 17. Zdravkovic V, Pantovic S, Rosic G, et al. Histamine blood concentration in ischemic heart disease patients. J Biomed Biotechnol. 2011;2011:315709.
  • 18. Ma HT, Beaven MA. Regulation of Ca2+ signaling with particular focus on mast cells. Crit Rev Immunol. 2009;29:155-86.
  • 19. Layritz CM, Hagel AF, Graf V, et al. Histamine in atrial fibrillation (AF)--is there any connection? Results from an unselected population. Int J Cardiol. 2014;172:e432-e433.
  • 20. Rohr SM, Rich MW, Silver KH. Shortness of breath, syncope, and cardiac arrest caused by systemic mastocytosis. Ann Emerg Med. 2005;45:592-4.
  • 21. Jani Y, Rexhepi A, PocestaBKamberi A, et al. C-reactive protein is associated with ventricular repolarization dispersion among patients with metabolic syndrome. J Cardiol Cardiovasc Med. 2019;2:043-052.
  • 22. Zheng LH, Yao Y, Wu LM, et al. Relationships of High-sensitive C-reactive Protein and P-wave Dispersion in Lone Atrial Fibrillation. Chin Med J (Engl). 2015;128:1450-4.
  • 23. Lazzerini PE, Laghi-Pasini F, Acampa M, et al. Systemic Inflammation Rapidly Induces Reversible Atrial Electrical Remodeling: The Role of Interleukin-6-Mediated Changes in Connexin Expression. J Am Heart Assoc. 2019;8:e011006.
  • 24. Puxeddu I, Pratesi F, Ribatti D, et al. Mediators of Inflammation and Angiogenesis in Chronic Spontaneous Urticaria: Are They Potential Biomarkers of the Disease? Mediators Inflamm. 2017;2017:4123694.
  • 25. Kasperska-Zajac A, Sztylc J, Machura E, et al. Plasma IL-6 concentration correlates with clinical disease activity and serum C-reactive protein concentration in chronic urticaria patients. Clin Exp Allergy. 201;41:1386- 91.
  • 26. Kolkhir P, Altrichter S, Hawro T, et al. C-reactive protein is linked to disease activity, impact, and response to treatment in patients with chronic spontaneous urticaria. Allergy. 2018;73:940-8.
  • 27. Birklein F, Schlereth T. Autonomic Effects on the Skin. In: Granstein R.D., Luger T.A. (eds) Neuroimmunology of the Skin. Springer, Berlin, Heidelberg, 2009;23-32.
  • 28. Leal Â, Carvalho M, Rocha I, et al. H.Inflammation and autonomic function. In: Autonomic nervous system. InTech, 2018.
  • 29. Mano T, Iwase S, Toma S. Microneurography as a tool in clinical neurophysiology to investigate peripheral neural traffic in humans. Clin Neurophysiol. 2006;117:2357-84.
  • 30. Shen MJ, Zipes DP. Role of the autonomic nervous system in modulating cardiac arrhythmias. Circ Res. 2014;114:1004-21.
  • 31. Minnei F, Wetzels C, De Hertogh, G et al. Chronic urticaria is associated with mast cell infiltration in the gastroduodenal mucosa. Virchows Arch. 2006;448:262-8.
  • 32. Williams RM, Berthoud HR, Stead RH. Vagal afferent nerve fibres contact mast cells in rat small intestinal mucosa. Neuroimmunomodulation. 1997;4:266-70.
  • 33. Konstantinou GN, Konstantinou GN. Psychological Stress and Chronic Urticaria: A Neuro-immuno-cutaneous Crosstalk. A Systematic Review of the Existing Evidence. Clin Ther. 2020;42:771-82.
  • 34. Buckley U, Shivkumar K. Stress-induced cardiac arrhythmias: The heartbrain interaction. Trends Cardiovasc Med. 2016;26:78-80.
  • 35. Yang HY, Sun CC, Wu YC, et al. Stress, insomnia, and chronic idiopathic urticaria--a case-control study. J Formos Med Assoc. 2005;104:254-63.
  • 36. Kini SP, DeLong LK, Veledar E, et al. The impact of pruritus on quality of life: the skin equivalent of pain. Arch Dermatol. 2011;147:1153-6.
Medicine Science-Cover
  • ISSN: 2147-0634
  • Yayın Aralığı: 4
  • Başlangıç: 2012
  • Yayıncı: Effect Publishing Agency ( EPA )
Sayıdaki Diğer Makaleler

Efficacy of unenhanced computed tomography features in distinguishing distal ureteric stones from phleboliths

Cemil OKTAY, Mahmut ÇORAPLI, Ali TUTUŞ

An investigation of the effects of total hip arthroplasty with femoral shortening in unilateral Crowe type-IV dysplastic hips on sagittal spinopelvic parameters

Ferdi DİRVAR, Hakan AKGÜN, Furkan YAPICI, Deniz KARGIN, Alper KÖKSAL, Osman ÇİMEN, Kadir ABUL

Follow-up and treatment of primary HIV infection in Pregnancy

Sibel ALTUNIŞIK TOPLU, Yasemin ERSOY, Esra SAĞLAM KANDEMİR

SARS-Cov-2 and hearing loss: Two sibling cases

Ayşe GÜRBÜZ YENİÇERİ, Mehmet Güney ŞENOL

Spondyloarthritis recovering after scorpion sting: A case report

Burcu KAYHAN TETİK, Nur PAKSOY

Working environment-related leisure time satisfaction levels and health behaviors of university office workers and ergonomic solutions

Cihan ÖNEN, Erhan DİNÇER, Muhammed Bahadır SANDIKÇI

The effect of mesenchymal stem cell-lyophilizate on the proliferation of A549 cells by regulation of JAK-STAT3 signaling pathway

Fatma Nilay TUTAK, Haluk ULUCA

Blood cell indices in High-Grade Squamous Intraepithelial Lesions

Ali YAVUZCAN, Sinem KANTARCIOĞLU COŞKUN, Zerrin GAMSIZKAN, Gökhan ERDEMİR

The role of component positions in revision hip arthroplasty; Minimum 5-year follow-up

Fahri EMRE, Erkan Sabri ERTAŞ, Murat BOZKURT

Association of sarcopenia with geriatric syndromes and neutrophil / lymphocyte ratio

Hakan YAVUZER, Veysel SUZAN, Bahar BEKTAN KANAT