Cardiac heterogeneity in patients with chronic urticaria; A perusal of P wave and QT dispersions

Cardiac heterogeneity in patients with chronic urticaria; A perusal of P wave and QT dispersions

Data on how the heart is affected in Chronic Urticaria (CU), a common annoying chronic dermatological disease, is quite limited. The electrocardiographic parameters; P wave dispersion (PWD) and QT dispersion (QTD) have been consistently reported to be predictive for cardiac arrhythmias and morbidity. We aimed to detect asymptomatic cardiovascular involvement in terms of predisposition to arrhythmias in chronic urticaria. This cross-sectional study included 128 individuals: 64 with CU and 64 healthy controls. 12-lead surface electrocardiogram and Doppler echocardiography were performed on patients and controls. All of the cardiologic parameters such as P wave, PWD, QTD and corrected QTD (QTDc) parameters were obtained from ECG measurements. Maximum P wave duration and PWD were found to be higher in CU patients than controls (P= 0.035 and P

___

  • 1. Radonjic-Hoesli S, Hofmeier KS, Micaletto S, et al. Urticaria and Angioedema: an Update on Classification and Pathogenesis. Clin Rev Allergy Immunol. 2018;54:88-101.
  • 2. Jafilan L, James C. Urticaria and Allergy-Mediated Conditions. Prim Care. 2015;42:473-83.
  • 3. Kocaturk E, Grattan C. Is chronic urticaria more than skin deep? Clin Transl Allergy. 2019;9:48.
  • 4. Chang HW, Cheng HM, Yen HR, et al. Association between chronic idiopathic urticaria and hypertension: A population-based retrospective cohort study. Ann Allergy Asthma Immunol. 2016;116:554-8.
  • 5. Erxun K, Wei L, Shuying Q. Kounis Syndrome Caused by Chronic Autoimmune Urticaria: A Case Report. J Emerg Med. 2016;50:37-40.
  • 6. Kounis NG, Koniari I, Tzanis G, et al. Anaphylaxis-induced atrial fibrillation and anesthesia: Pathophysiologic and therapeutic considerations. Ann Card Anaesth. 2020;23:1-6.
  • 7. Okutucu S, Aytemir K, Oto A. P-wave dispersion: What we know till now? JRSM Cardiovasc Dis. 2016;5:2048004016639443.
  • 8. Baumert M, Porta A, Vos MA, et al. QT interval variability in body surface ECG: measurement, physiological basis, and clinical value: position statement and consensus guidance endorsed by the European Heart Rhythm Association jointly with the ESC Working Group on Cardiac Cellular Electrophysiology. Europace. 2016;18:925-44.
  • 9. Atiga WL, Calkins H, Lawrence JH, et al. Beat-to-beat repolarization lability identifies patients at risk for sudden cardiac death. J Cardiovasc Electrophysiol. 1998;9:899-908.
  • 10. Erre GL, Piras A, Piga M, et al. QT and QT dispersion intervals in longstanding and moderately active rheumatoid arthritis: results from a multicentre cross-sectional study. Clin Exp Rheumatol. 2020;38:516-22.
  • 11. Zhan X, Li C, Wu Q. Cardiac urticaria caused by eucleid allergen. Int J Clin Exp Med. 2015;8:21659-63.
  • 12. Zuberbier T, Aberer W, Asero R, et al. The EAACI/GA²LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria. Allergy. 2018;73:1393-414.
  • 13. Galderisi M, Cosyns B, Edvardsen T, et al. Standardization of adult transthoracic echocardiography reporting in agreement with recent chamber quantification, diastolic function, and heart valve disease recommendations: an expert consensus document of the European Association of Cardiovascular Imaging. Eur Heart J Cardiovasc Imaging. 2017;18:1301-10.
  • 14. Akin C. Mast cell activation disorders. J Allergy Clin Immunol Pract. 2014;2:252-7.e1;quiz 258.
  • 15. Janicki JS, Brower GL, Levick SP. The emerging prominence of the cardiac mast cell as a potent mediator of adverse myocardial remodeling. Methods Mol Biol. 2015;1220:121-39.
  • 16. Wolff AA, Levi R. Histamine and cardiac arrhythmias. Circ Res. 1986;58:1- 16.
  • 17. Zdravkovic V, Pantovic S, Rosic G, et al. Histamine blood concentration in ischemic heart disease patients. J Biomed Biotechnol. 2011;2011:315709.
  • 18. Ma HT, Beaven MA. Regulation of Ca2+ signaling with particular focus on mast cells. Crit Rev Immunol. 2009;29:155-86.
  • 19. Layritz CM, Hagel AF, Graf V, et al. Histamine in atrial fibrillation (AF)--is there any connection? Results from an unselected population. Int J Cardiol. 2014;172:e432-e433.
  • 20. Rohr SM, Rich MW, Silver KH. Shortness of breath, syncope, and cardiac arrest caused by systemic mastocytosis. Ann Emerg Med. 2005;45:592-4.
  • 21. Jani Y, Rexhepi A, PocestaBKamberi A, et al. C-reactive protein is associated with ventricular repolarization dispersion among patients with metabolic syndrome. J Cardiol Cardiovasc Med. 2019;2:043-052.
  • 22. Zheng LH, Yao Y, Wu LM, et al. Relationships of High-sensitive C-reactive Protein and P-wave Dispersion in Lone Atrial Fibrillation. Chin Med J (Engl). 2015;128:1450-4.
  • 23. Lazzerini PE, Laghi-Pasini F, Acampa M, et al. Systemic Inflammation Rapidly Induces Reversible Atrial Electrical Remodeling: The Role of Interleukin-6-Mediated Changes in Connexin Expression. J Am Heart Assoc. 2019;8:e011006.
  • 24. Puxeddu I, Pratesi F, Ribatti D, et al. Mediators of Inflammation and Angiogenesis in Chronic Spontaneous Urticaria: Are They Potential Biomarkers of the Disease? Mediators Inflamm. 2017;2017:4123694.
  • 25. Kasperska-Zajac A, Sztylc J, Machura E, et al. Plasma IL-6 concentration correlates with clinical disease activity and serum C-reactive protein concentration in chronic urticaria patients. Clin Exp Allergy. 201;41:1386- 91.
  • 26. Kolkhir P, Altrichter S, Hawro T, et al. C-reactive protein is linked to disease activity, impact, and response to treatment in patients with chronic spontaneous urticaria. Allergy. 2018;73:940-8.
  • 27. Birklein F, Schlereth T. Autonomic Effects on the Skin. In: Granstein R.D., Luger T.A. (eds) Neuroimmunology of the Skin. Springer, Berlin, Heidelberg, 2009;23-32.
  • 28. Leal Â, Carvalho M, Rocha I, et al. H.Inflammation and autonomic function. In: Autonomic nervous system. InTech, 2018.
  • 29. Mano T, Iwase S, Toma S. Microneurography as a tool in clinical neurophysiology to investigate peripheral neural traffic in humans. Clin Neurophysiol. 2006;117:2357-84.
  • 30. Shen MJ, Zipes DP. Role of the autonomic nervous system in modulating cardiac arrhythmias. Circ Res. 2014;114:1004-21.
  • 31. Minnei F, Wetzels C, De Hertogh, G et al. Chronic urticaria is associated with mast cell infiltration in the gastroduodenal mucosa. Virchows Arch. 2006;448:262-8.
  • 32. Williams RM, Berthoud HR, Stead RH. Vagal afferent nerve fibres contact mast cells in rat small intestinal mucosa. Neuroimmunomodulation. 1997;4:266-70.
  • 33. Konstantinou GN, Konstantinou GN. Psychological Stress and Chronic Urticaria: A Neuro-immuno-cutaneous Crosstalk. A Systematic Review of the Existing Evidence. Clin Ther. 2020;42:771-82.
  • 34. Buckley U, Shivkumar K. Stress-induced cardiac arrhythmias: The heartbrain interaction. Trends Cardiovasc Med. 2016;26:78-80.
  • 35. Yang HY, Sun CC, Wu YC, et al. Stress, insomnia, and chronic idiopathic urticaria--a case-control study. J Formos Med Assoc. 2005;104:254-63.
  • 36. Kini SP, DeLong LK, Veledar E, et al. The impact of pruritus on quality of life: the skin equivalent of pain. Arch Dermatol. 2011;147:1153-6.
Medicine Science-Cover
  • ISSN: 2147-0634
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 2012
  • Yayıncı: Effect Publishing Agency ( EPA )
Sayıdaki Diğer Makaleler

Transition clinic in pediatric onset multiple sclerosis: Opinions of pediatric neurologists and neurologists

İsmail SOLMAZ

Early warning triad for pulmonary microemboli in COVID-19 pneumonia: Pulmonary artery diameter, D-dimer and NT-proBNP

Mehmet KALAYCI, Hakan AYYILDIZ, Mustafa TİMURKAAN, Esra SUAY TİMURKAAN, Gülsüm ALTUNTAŞ

Does ABO blood type is a novel risk factor for osteoporosis or low bone density among postmenopausal women or not?

Bilgin Bahadır BAŞGÖZ, Buse HACIOĞLU, Cevdet Furkan KÖŞKER, Musa Barış AYKAN, Semra İNCE, İlker TAŞÇI, Ahmet Burak BİLEKLİ, Alev ÇINAR

Identification of marker proteins in preterm and term birth: Relationship of rankl and HSP70 in the cord blood

Selçuk GÜREL, Barış UZUNOK

SBRT in the treatment of prostate cancer nodal relapse: A single-center experience and a brief literature review

Tarık KARGIOĞLU, Gonca ALTINIŞIK İNAN, Hüseyin Furkan ÖZTÜRK, Feyza YAŞAR DAŞGIN

Association of sarcopenia with geriatric syndromes and neutrophil / lymphocyte ratio

Hakan YAVUZER, Veysel SUZAN, Bahar BEKTAN KANAT

Green synthesis and antimicrobial effects of silver nanoparticles by pumpkin cucurbita maxima fruit fiber

Ayşe BARAN, Necmettin AKTEPE

Evaluation of the results of the proximal femoral nail surgery for intertrochanteric femur fractures

İbrahim ULUSOY, Aybars KIVRAK, Erhan YILMAZ

Posterior root tear of the medial and lateral meniscus on magnetic resonance imaging of 10,980 knee

Ömer Cahit ÇITIR, Osman DEMİR, Orhan BALTA, Eyüp Çağatay ZENGİN, Mehmet Burtaç EREN, Harun ALTINAYAK

Antimicrobial effective nanoparticles: Mechanisms and recent achievements

Nurgül K. BAKIRHAN, Nilgün ÜNAL, Merve ŞAVLUK, Çiğdem YÜCEL