Spondyloarthritis recovering after scorpion sting: A case report

Scorpion venom, which is also utilized in Traditional Chinese Medicine, has been an efficient alternative medicine practice passed down from generation to generation since the Ancient Roman Period. Scorpion venom is now being investigated as a raw material (drug precursors) in a variety of sectors including new-generation pharmaceuticals. We present a 63-year-old male patient who had sacroiliitis symptoms that went away after a scorpion sting, and who recovered completely during follow-up. Apart from developing scorpion venom as a complementary therapy to existing medical techniques in the treatment of chronic inflammatory illnesses, more research into the effects of this prospective pharmaceutical on these diseases is required.

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1. Chippaux JP, Goyffon M. Epidemiology of scorpionism: A global appraisal. Acta Trop. 2008;107:71–9.
2. Ahmadi S, Knerr JM, Argemi L, et al. Scorpion Venom: Detriments and benefits. Biomedicines. 2020;8:118.
3. Meki AR, Mohey El-Dean ZM. Serum interleukin-1beta, interleukin-6, nitric oxide and alpha1-antitrypsin in scorpion envenomed children. Toxicon. 1998;36:1851-9.
4. Pucca MB, Bertolini TB, Cerni FA, et al. Immunosuppressive evidence of Tityus serrulatus toxins Ts6 and Ts15: insights of a novel K(+) channel pattern in T cells. Immunology. 2016;147:240-50.
5. Xiao M, Ding L, Yang W, et al. St20, a new venomous animal derived natural peptide with immunosuppressive and anti-inflammatory activities. Toxicon. 2017;127:37-43.
6. Kınıklı G. Spondyloarthropathies, rheumatology, Ankara university faculty of medicine publications. 2013, p:252-63.
7. Valizade M, Raesi Vanani A, Rezaei M, et al. Mesobuthus eupeus venom induced injury in the colorectal carcinoma cell line (HT29) through altering the mitochondria membrane stability. Iran J Basic Med Sci. 2020;23:760-7.
8. Khosravi M, Mayahi M, Kaviani F, Nemati M. The Effects of Isolated Fractions of Mesobuthus eupeus Scorpion venom on humoral immune response. J Arthropod Borne Dis. 2017;11:497-503.
9. Mirshafiey A. Venom therapy in multiple sclerosis. Neuropharmacology. 2007;53:353-61.
10. Zhao Y, Huang J, Yuan X,et al. Toxins Targeting the Kv1.3 Channel: Potential immunomodulators for autoimmune diseases toxins Toxins (Basel). 2015;19;7:1749-64.
11. Shen B, Cao Z, Li W, et al. Treating autoimmune disorders with venomderived peptides. Expert Opin Biol Ther. 2017;17:1065-75.