Risk Faktörü Olmadan Meydana Gelen Plasenta Dekolmanı Önceden Öngörülebilir mi?
Literatürde gebeliğin birinci ve ikinci trimesterindeki serum analit düzeylerinin preeklampsi ve intrauterin gelişme geriliği gelişen olgular başta olmak üzere plasentasyon bozuklukları ile ilişkili olduğunu ortaya koyan çok sayıda çalışma olmasına karşılık bu belirteçlerin plasental dekolman olgularını öngörmedeki rolü tartışmalıdır. Bu çalışmanın amacı; plasental dekolman nedeniyle sezaryan uygulanan bazal herhangi bir risk faktörü olmaksızın gelişen bir obstetrik popülasyonda ilk ve ikinci trimester anöplodi taramasında kullanılan belirteçlerin dekolmanı öngörmedeki rolünü araştırmaktır. Sezaryen ile doğum yapan 120 term gebe kadının dahil edildiği bu retrospektif çalışmada hasta ve kontrol grubunda 1. ve 2. trimester serum belirteç düzeyleri karşılaştırılmıştır. Fetal ense saydamlığı ölçüm değeri dekolman grubunda kontrol grubuna göre anlamlı olarak yüksek bulunmuştur. Bu çalışmada bilinen risk faktörleri olmadan termde plasenta dekolmanı gelişen olguları ön görmede birinci ve ikinci trimesterda bakılan biyomarkerlardan ziyade fetal ense saydamlığında artışın önemli olabileceği vurgulanmaktadır.
Prediction of Placenta Abrubtion without Risk Factors
Many studies in the literature have shown the assosiation between serum analits of first and second trimester screening test with intra uterin growth retardation and abrubtio placenta.However these markers role in the predicting of placental abrubtion is unclear. We aimed in this study,is there any relationship between placental abrubtion without risk factors and first and seconder trimester screening markers. 120 term pregnant women who gave birth by Caesarean section has been included in this retrospective study, patients and controls were compared for the 1st and 2nd trimester serum markers levels. Fetal nuchal translucency measurements were significantly higher in the study group than control group. This study emphasizes that increased fatal nuchal transluency is more important than serum biomarkers of first and second trimester screening tests.
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- 1. Riihimäki O, Metsäranta M, Ritvanen A, Gissler M, Luukkaala T, Paavonen J, Nuutila M, Andersson S, Tikkanen M. Increased prevalence of majör congenital anomalies in births with placental abruption. Obstet Gynecol. 2013;122(2 Pt 1):268-74.
- 2. Bolin M, Åkerud H, Cnattingius S, Stephansson O, Wikström AK. Hyperemesis Gravidarum and risks of placental dysfunction disorders: a population-based cohort study. BJOG. 2013;120(5):541-7.
- 3. Tikkanen M, Riihimäki O, Gissler M, Luukkaala T, Metsäranta M, Andersson S, Ritvanen A, Paavonen J, Nuutila M. Decreasing incidence of placental abruption in Finland during 1980-2005. Acta Obstet Gynecol Scand. 2012;91(9):1046-52.
- 4. Pariente G, Wiznitzer A, Sergienko R,Mazor M, Holcberg G, Sheiner E. Placental abruption: critical analysis of risk factors and perinatal outcomes. J Matern Fetal Neonatal Med. 2011;24(5):698-702.
- 5. Ananth CV, Berkowitz GS, Savitz DA, Lapinski RH. Placental abruption and adverse perinatal outcome. JAMA. 1999; 282(17):1646-51.
- 6. Elsasser DA, Ananth CV, Prasad V, Vintzileos AM; New Jersey-Placental Abruption Study Investigators. Diagnosis of placentalabruption: relationship between clinical and histopathological findings. Eur J Obstet Gynecol Reprod Biol. 2010;148(2):125-30.
- 7. Martinez-Biarge M, Madero R, González A,Quero J, García-Alix A. Perinatal morbidity and risk of hypoxic-ischemic encephalopathy associated with intrapartum sentinel events. Am J Obstet Gynecol. 2012;206(2):148.e1-7.
- 8. Raisanen S, Gissler M, Saari J, Kramer M, Heinonen S. Contribution of risk factors to extremely, very and moderately preterm births--register-based analysis of 1,390,742 singleton births. PLoSOne. 2013;8(4):e60660.
- 9. Yılmaz M, Isaoglu U, Delibas IB, Uluğ P, İngeç M, Al RA. Dekolman Plasenta: Epidemiyoloji, risk faktörlerinin analizi, fetal ve maternal sonuçlar. Sakaryamj. 2013;3(3):126-30.
- 10. Dugoff L, Hobbins JC, Malone FD, , Porter TF, Luthy D, Comstock CH, Hankins G, Berkowitz RL, Merkatz I, Craigo SD, Timor-Tritsch IE,Carr SR, Wolfe HM, Vidaver J, D'Alton ME. First-trimester maternal serum PAPP-A and free-beta subunit human chorionic gonadotropin concentrations and nuchal translucency are associated with obstetric complications: a population-based screening study (The FASTER Trial). Am J Obstet Gynecol. 2004;191(4):1446-51.
- 11. Ranta JK, Raatikainen K, Romppanen J,Pulkki K, Heinonen S. Decreased PAPPA is Associated with preeclampsia, prematüre delivery and small for gestational age infants but not with placental abruption. Eur J Obstet Gynecol Reprod Biol. 2011;157(1):48-52.
- 12. Odibo AO, Zhong Y , Longtine M, Tuuli M, Odibo L, Cahill AG, Macones GA, Nelson DM. First trimester serum analytes, biophysical tests and the association with pathological morphometry in the placenta of pregnancies with preeclampsia and fetal growth restriction. Placenta. 2011;32(4):333-8.
- 13. Blumenfeld YJ, Baer RJ, Druzin ML, El-Sayed YY, Lyell DJ, Faucett AM, Shaw GM, Currier RJ, Jelliffe-Pawlowski LL. Association between maternal characteristics, abnormal serum aneuploidy analytes, and placental abruption. Am J Obstet Gynecol. 2014;211(2):144.e1-9.
- 14. García-Cavazos R, Colín-Valenzuela A, Espino y Sosa S. Alpha-fetoprotein as an early predictor of adverse perinatal outcome. Ginecol Obstet Mex. 2010;78(5):268-74.
- 15. Signore C, Mills JL, Qian C, Yu K, Lam C, Epstein FH, Karumanchi SA, LevineRJ. Circulating angiogenic factors and placental abruption. Obstet Gynecol. 2006;108(2):338-44.
- 16. Khong SL, Kane SC, Brennecke SP, da SilvaCosta F. First-trimester uterine artery Doppleranalysis in the prediction of later pregnancy complications. Dis Markers. 2015;2015:679730.
- 17. Lithner CU, Kublickas M. Pregnancy outcome for fetuses with increased nuchal translucency but normal karyotype. J Med Screen. 2015 Jul 20. pii: 0969141315595826. PMID: 26195563
- 18. Ayräs O, Tikkanen M, Eronen M, Paavonen J, Stefanovic V. Increased nuchal translucency and pregnancy outcome: a retrospective study of 1063 consecutive singleton pregnancies in a single referral institution. Prenat Diagn. 2013;33(9):856-62.