Erguvan-Önal R, Önal Ç, Şener M, Mızrak Duran E, Aydın NE, Rezzan ERGUVAN-ÖNAL, Çağatay ÖNAL, Metin ŞENER, Bülent MIZRAK, Erol DURAN, Nasuhi Engin AYDIN

Primitive Neuroectodermal Tumor Coexistent with Anaplastic Ganglioglioma

Primitive neuroectodermal tumors are among the most common tumors of childhood and the most frequent location of them is cerebellum. Supratentorial primitive neuroectodermal tumors are uncommon. These tumors, regardless of site of origin, may show differentiations towards different cell lines such as glial, neuronal, and mesenchymal. To our knowledge, there is only one case in the literature describing ganglioglial differentiation in a cerebellar medulloblastoma. The presented report discloses a supratentorial primitive neuroectodermal tumor coexistent with anaplastic ganglioglioma in a 46-year-old man. Both components of the tumor disappeared after radiotherapy, with a proceedent glioblastomatous differentiation in the follow-up period.

Keywords:

primitive neuroectodermal tumor, anaplastic ganglioglioma, glioblastoma multiforme, brain,

PDF

___

Rorke LB, Gilles FH, Davis RL, Becker LE. Revision of the World Health Organization Classification of Brain Tumors for Childhood Brain Tumors. Cancer 1985; 56:1869-86.
Kudo M, Shimizu M, Akutsu Y, Imaya H, Chen MN, Miura M. Ganglioglial differentiation in medulloblastoma. Acta Pathol Jpn 1990; 40(1):50-6.
Rorke LB, Hart MN, McLendon RE. Supratentorial primitive neuroectodermal tumour (PNET). In: Kleihues P, Cavenee WK (eds). World Health Organization Classification of Tumours, Pathology & Genetics, Tumours of the Nervous System. Lyon: IARC Press; 2000: 141-4.
Becker LE, Hinton D. Primitive neuroectodermal tumors of the central nervous system. Hum Pathol 1983; 14: 538-50.
Jay V, Pienkowska M, Becker L, Zielenska M. Primitive neuroectodermal tumors of the cerebrum and cerebellum: abscence of t(11;22) translocation by RT-PCR analysis. Mod Pathol 1995; 8(5): 488-91.
Gyure KA, Prayson RA, Estes ML. Extracerebellar primitive neuroectodermal tumors: A clinicopathologic study with bcl-2 and CD99 immunohistochemistry. Ann Diagn Pathol 1999; 3(5):276-80.
Holl T, Kleihues P, Yasargil MG, Wiestler OD. Cerebellar medullomyoblastoma with advanced neuronal differentiation and hamartomatous component; Acta Neuropathol (Berl) 1991;82(5):408-13.
Greenberg MS. Handbook of Neurosurgery. 5th ed. Ontario, Canada: Webcome Limited; 2001: 451.
Pearl GS, Mirra SS, Miles ML. Glioblastoma multiforme occurring 13 years after treatment of a medulloblastoma. Neurosurgery 1980; 6(5):546-51.
Bhangui GR, Roy S, Tandon PN. Multiple primary tumors of the brain including a medulloblastoma in the cerebellum. Cancer 1977; 39(1):293-7.
Provias JP, Becker LE. Cellular and Molecular Pathology of Medulloblastoma. J Neurooncol 1996; 29:35-43.
Packer RJ, Sutton LN, Rorke LB, Littman PA, Sposto R, Rosenstock JG, Bruce DA, Schut L. Prognostic importance of cellular differentiation in medulloblastoma of childhood. J Neurosurg 1984; 61(2):296-301.