Ozdemir B, Celbis O, Onal R, Mizrak B, Karakoc Y4 -

Multiple Organ Pathologies Underlying in Sudden Natural Deaths

We aimed to investigate the relationships between Polycystic Ovary Syndrome (PCOS) and oxidative stress status, metabolic profile and cardiovascular risk factors in patients with polycystic ovary syndrome Methods: We measured Body Mass Index (BMI), glucose, cholesterol, triglyceride, HDL, LDL, high sensitive CRP (hsCRP), insulin, AST and ALT, Malondialdehyde (MDA), erythrocyte reduced glutathione (GSH), Nitric Oxide (NO) levels in PCOS patients and in normal individuals. We used spectrophotometrical method to determine glucose, cholesterol, triglyceride, HDL, LDL, AST and ALT levels. Nepholometrical method was used to measure hsCRP. Immunoassay method was used for insulin. Oxidant status was evaluated by using erythrocyte MDA and NO levels, while antioxidant status was evaluated by GSH levels. Results: Study population were consist of 32 women with PCOS (Study group) and 32 healthy volunteers (Control group). In study group, we found statistically higher levels of MDA, NO (p<0.001) and lower levels of GSH (p<0.001) compared to those of controls. hsCRP, insulin (p<0.001) and triglyceride (p<0.05) levels were statistically higher in study group. We also observed a statistically higher BMI in women with PCOS (p<0.05). Conclusion: Our results revealed that PCOS is associated with imbalanced oxidative/antioxidative status, impaired metabolic profile and increased cardiovascular risk factors.

Anahtar Kelimeler:

PCOS, oxidants, antioxidants, MDA, NO, GSH

Multiple Organ Pathologies Underlying in Sudden Natural Deaths

Keywords:

PCOS, oxidants, antioxidants, MDA, NO, GSH,

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